Longitudinal Plasma Proteomic Profiling in Aortic Stenosis: Identification of Signatures Associated with Disease Progression and Clinical Outcomes.
About the Project
This project aims to investigate the proteomics associated with the development and progression of aortic stenosis (AS), a degenerative heart valve disease. To date, no pharmacological treatment exists to slow or stop the progression of this disease, which affects approximately 2% of the population. AS is a complex and actively regulated process involving the interaction of several signaling pathways, including lipid infiltration and retention, inflammation, activation of osteogenic genes, and active mineralization of valvular tissues.
The PROGRESSA clinical study (Study of Metabolic Factors Determining the Progression of Aortic Stenosis) is one of the most extensive clinical studies in the world focused on the progression of AS. Given the large amount of biological material collected to date, a specific study on the proteomics of this disease will be conducted.
The selected student will work in collaboration with the teams of Dr Sebastien Theriault (supervisor) and Dr Philippe Pibarot (co-supervisor) to carry out the analyses. The student will also participate in the writing of scientific manuscripts and in presenting research findings at conferences.
Target demographic: Our research project facility is in Quebec city in Canada. The student will be attending University Laval. We are targeting postgraduate students in Canada who holds a B.Sc or M.Sc in bioinformatics or related fields and which have equally communication skills in both French and English is essential. The candidate must have a excellent academic record in order to obtain a salary scholarship. The student must have knowledge of R software and Linux, as well as experience in statistical analysis are considered assets. The candidate must demonstrate motivation, autonomy and rigor: demonstrate dedication to research, initiative, and the ability to work as part of a team, process strong organizational skills and be proactive. Starting date: September 2026 (autumn session).
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