About the Project
Summary
This project is focused on establishing the role of mitochondrial genetic variants in determining the outcome of MS.
Project Aims
Genome-Wide Association (GWAS) in multiple sclerosis have identified over 200 autosomal genetic variants that influence the disease but have not systematically considered the role of the mitochondrial genome, despite the fact that it is well established that pathogenic mitochondrial variants, such as those causing Leber’s hereditary optic neuropathy (LHON), can influence the outcome of the disease. In this project we will use a specifically designed mitochondrial variant calling pipeline (PMID: 34002094) to analyse whole genome sequence data (30x) from 3,800 patients with multiple sclerosis and correlate observed common variation with clinical course.
(PhD or MPhil)
Funding Notes
For academic year October 27/28;
Gates US applications (round 1) close 14th October 26, further information available via Gates Website.
Cambridge Trust, Gates Cambridge (round 2) deadline 8th December 26 to be eligible for funding. If you apply after the funding deadlines you will not be eligible for the Cambridge Funding competition, please indicate in your application all the funding you are eligible for. You can also check funding search Search - Postgraduate Funding Search.
Funding is not available for Lent or Easter 27 places as the funding deadline for these has already passed, you will need to have other funding in place to support your studies