MSc by Research: Human heart organoids for drug discovery in heart failure

About the Project

Study of heart failure and heart attack is extremely difficult. Moreover, only 5% of all drugs tested in animal models are approved for human applications. Thus, we urgently need cell models to efficiently and effectively evaluate drug effects like toxicity. The cells that build the heart, called cardiomyocytes, were one of the first cells differentiated from human induced pluripotent stem cells. Developing these further into heart organoids enables not only human-specific context, but also the study of human tissue in 3D. We are looking for a motivated and excellent candidate to characterise an organoid model for heart failure with us. This project would entail initial characterisation of heart organoids subject to heart failure using standard cell biology and biochemistry approaches. We would aim to develop an appropriate model for initial screens of small molecule (drug) libraries by phenotypic screening. Successful candidate will obtain mastery in the state-of-the-art stem cell differentiation approaches, general cell biology and biochemistry, and phenotypic imaging. The successful completion of this project will give insights into improving drug screening processes for humans in a state-of-the-art model cell system.

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.

Please see our website for further details on the programme and how to apply:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

When you complete your application form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application, please note our intake deadlines on the ‘how to apply’ section of our website.