MSc by Research: Unravelling the molecular mechanism underpinning Ubiquitin-like fusion protein proteolysis

About the Project

The Maniaci Lab tackles one of the big puzzles in cell biology: How can cells create a vast diversity of proteins from a limited genetic blueprint? This diversity is essential for life and is largely achieved through post-translational modifications (PTMs) – molecular “tags” added to proteins after they’re made. PTMs allow proteins to adopt different shapes, locations, and functions, enabling cells to adapt to changing conditions and perform complex tasks. However, when PTMs are improperly regulated, it can disrupt cellular balance, leading to diseases such as cancer and neurodegenerative disorders. Despite their importance, many PTMs remain unknown or poorly understood, and uncovering them could transform our understanding of health and disease.

In this project, we will explore an exciting new PTM mechanism that our lab recently discovered, known as “cleave-to-modify.” This pathway involves the strategic processing of proteins that contain ubiquitin-like domains, setting the stage for further modifications that allow precise control over protein functions. We aim to dissect this mechanism in detail, identifying the molecular players involved and understanding how they contribute to cellular regulation. By mapping out this pathway, we hope to uncover novel strategies for influencing protein behavior, opening up new avenues for targeted therapies.

The potential impact of this project is far-reaching. By illuminating how cells manage protein diversity and function, this work could identify novel drug targets for treating diseases linked to PTM dysregulation. Imagine a future where we can precisely manipulate PTMs to halt cancer progression or counteract neurodegenerative damage – that’s the kind of possibility this project could unlock. For students, this is an opportunity to contribute to high-impact research at the cutting edge of cell biology and biomedical science.

Throughout this project, students will develop a strong skill set across biochemistry, cell biology, and quantitative proteomics, using a custom toolkit designed in our lab to study the ubiquitin-like fusion protein system. The project provides a unique hands-on learning experience, integrating method development with real-world applications in disease research. Students will work within an interdisciplinary team, gaining exposure to diverse scientific approaches and insights. This is an ideal project for those who are curious about how cells work at the molecular level, excited to develop new skills, and eager to be part of research that could ultimately impact human health.

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.

Please see our website for further details on the programme and how to apply:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

When you complete your application form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application, please note our intake deadlines on the ‘how to apply’ section of our website.