The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural neurotoxins and their synthetic analogues act on ion channels in the nervous system and other excitable tissues. This project will study the modes and sites of action of the toxins and assess their suitability for development as novel therapeutic agents or pesticides. Sources of active compounds that we are presently…
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