PhD student - From brain circuits of threat to neurofeedback in humans

student to join a collaborative translational neuroscience project investigating how the brain controls responses to threat and stress. The project is part of a new programme aimed at strengthening the connection between fundamental neuroscience and clinical psychiatry. Maladaptive responses to threat are an important feature of psychiatric conditions such as anxiety disorders, PTSD and depression. In this project, we will identify brain regions that can regulate threat responses and investigate whether these regions can ultimately be targeted using real-time fMRI neurofeedback. The project provides a unique opportunity to work across the boundary between fundamental systems neuroscience and human translational neuroscience. What will you do You will first work at the Netherlands Institute for Neuroscience (NIN) in Amsterdam, in the laboratory of Prof. Alexander Heimel. Using mouse models of innate defensive behavior, you will identify a brain region that can regulate defensive behavior. You will use state-of-the-art approaches including behavioral analysis of innate defensive responses, activity-dependent neuronal tagging using TRAP2, viral and monosynaptic rabies tracing, optogenetic manipulation of neural circuits, fiber photometry and quantitative analysis of neural and behavioral data. In the second part of the project, you will work with Prof. David Linden and colleagues at Maastricht UMC+, translating the circuit identified in mice to humans. You will use 7T fMRI to translate the findings from the first part and develop a real-time fMRI neurofeedback paradigm through which participants learn to regulate the identified brain region. The ultimate aim is to develop a biologically grounded approach to neurofeedback in which targets are selected because they have a demonstrated causal role in controlling threat circuitry. The work may provide a foundation for future neurofeedback interventions in patients with stress-related psychiatric disorders. What will you contribute We are looking for a candidate who: has, or will soon obtain, a master's degree in neuroscience, biomedical sciences, medicine, psychology, cognitive neuroscience, or a related discipline has a strong interest in how neural circuits generate behavior is enthusiastic about working at the interface between animal and human neuroscience is interested in learning a broad range of experimental and computational techniques enjoys quantitative analysis and has or is willing to develop data-analysis skills wants to interact with psychiatrists and clinical psychologists to develop new paradigms has good communication skills and enjoys working collaboratively has a good command of spoken and written English Experience with animal behavior, optogenetics, viral approaches, microscopy, programming/data analysis, MRI or human experimental research would be an advantage, but we do not expect applicants to already have expertise in all these areas. More important is a strong scientific curiosity and willingness to learn techniques from both animal systems neuroscience and human neuroimaging. Because part of the project involves experimental work with mice, the candidate should be comfortable working with laboratory animals. What we offer You will join two complementary and highly interactive research environments. At the Netherlands Institute for Neuroscience, you will receive training in causal circuit neuroscience and the neural mechanisms underlying innate behavior. At Maastricht UMC+, you will gain expertise in human neuroimaging, high-field 7T MRI and real-time neurofeedback within a clinical neuroscience environment. The project includes regular interaction with both research groups and joint supervision throughout the PhD. The project is funded for four years. The first two years will primarily focus on circuit discovery and causal experiments in mice, followed by human circuit validation and neurofeedback experiments during years three and four. Some travel or/and movement allowance is budgeted for making the collaboration between Amsterdam and Maastricht smooth. You will have opportunities to present your work at international conferences, collaborate with researchers across neuroscience, psychiatry and neuroimaging, and develop a profile as a genuinely cross-species translational neuroscientist. Research environment The project is a collaboration between the group of Prof. Alexander Heimel at the Netherlands Institute for Neuroscience in Amsterdam and the group of Prof. David Linden at Maastricht UMC. The Heimel group investigates the neural circuits that transform sensory information and internal state into behavior, with particular expertise in visual and innate behaviors, circuit tracing and causal manipulation in mice. The Maastricht team has extensive expertise in fMRI neurofeedback, high-field imaging and clinical neuroscience, including subcortical neurofeedback targets. The project will also involve interaction with researchers experienced in real-time and 7T fMRI. Information For questions about the position, please contact Alexander Heimel (a.heimel@nin.knaw.nl) or David Linden (david.linden@maastrichtuniversity.nl). There is no deadline for the application, the vacancy will be closed if a suitable candidate has been found. Application You can apply via the Apply Now button, please submit: A motivation letter explaining why this project interests you A detailed CV, including a grade list Contact details of two academic referees, who can be contacted About the Netherlands Institute for Neuroscience The Netherlands Institute for Neuroscience is a leading fundamental neuroscience research institute, in the international and progressive city of Amsterdam. It provides a critical mass of scientists (spanning more than 27 nationalities) and neuroscience facilities, in a highly interactive, dynamic, multi-cultural environment, with English as the working language. Terms of employment Depending on education and experience the minimum salary is € 3.204 and the maximum salary is € 4.051 gross per month for a full-time appointment (scale P cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP. The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment). For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW. Applying for a Certificate of Good Conduct can be part of the employment procedure. Diversity & Inclusion The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy. We will not respond to any supplier enquiries based on this job advertisement. Working at KNAW The Royal Netherlands Academy of Arts and Sciences (KNAW) is the guardian and interpreter of science in the Netherlands.