Oncology, Cancer & Blood Diseases Institute - Cell & Immune Therapy – Physician-Scientist

clinical activities. We seek investigators whose work connects mechanistic discovery with therapeutic development and clinical translation. Research focused on brain tumors and other CNS malignancies or myeloid malignancies will be prioritized, although outstanding candidates working in other cancers will also be considered.

Research Environment

This recruitment is integrated into the growth and expansion of cellular and immunotherapy translational research programs at Cincinnati Children's. The candidate's research program will be highly integrated with the Division of Experimental Hematology and Cancer Biology (EHCB) and CBDI, as well as the University of Cincinnati Cancer Center (UCCC). A major resource for this effort is the Applied Gene and Cell Therapy Center (AGCTC), which provides infrastructure to accelerate gene and cell therapies toward the clinic, including product development, GMP manufacturing, analytical development, quality control, and regulatory support in new start of the art facility spanning approximately 55,000 square feet. Investigators also have access to advanced capabilities in genomics, single-cell technologies, genome engineering, proteomics, computational biology, human biospecimens, and preclinical disease models. The successful candidate will join a highly collaborative community spanning oncology, cancer biology, hematology, immunology, neuroscience, and gene and cell therapy. Together, these resources provide a strong environment for advancing discoveries from mechanistic studies through preclinical development and early-phase clinical investigation.

Candidate Profile

Applicants should have an MD, MD/PhD, or equivalent medical degree, with appropriate clinical training and board eligibility or certification relevant to pediatric oncology. We seek candidates conducting mechanistically rigorous research with a strong translational focus in cellular or immune therapy. Relevant areas include engineered T-cell, NK-cell, and other immune-cell therapies; tumor antigen and target discovery; immune engineering; tumor-immune interactions; and mechanisms of therapeutic response and resistance. Approaches designed to improve the efficacy, persistence, specificity, or safety of cellular and immune therapies are also of particular interest. Priority will be given to investigators applying these approaches to brain tumors/CNS malignancies or myeloid malignancies and to programs with a clear path from biological discovery to preclinical and clinical development.

Candidates at the Assistant Professor level should demonstrate an outstanding record of scientific accomplishment and strong potential to establish an independent, externally funded research program. Candidates at the Associate or Full Professor level should have an established record of impactful scholarship, extramural funding, mentorship, translational investigation, and scientific leadership.

About Cincinnati Children's

Cincinnati Children's is one of the nation's leading pediatric research institutions, with an internationally recognized research enterprise spanning basic discovery, translational science, and clinical investigation. The Cancer and Blood Diseases Institute integrates research and clinical programs in cancer biology, hematology, oncology, gene and cell therapy, and related disciplines to translate fundamental discoveries into improved therapies for children and young adults.

Faculty benefit from the extensive resources of the Cincinnati Children's Research Foundation and strong partnerships with the University of Cincinnati College of Medicine and University of Cincinnati Cancer Center. More information about research at Cincinnati Children's can be found at https://www.cincinnatichildrens.org/research.

Location

Cincinnati is a dynamic and affordable metropolitan area with a vibrant cultural and business community, nationally recognized schools, and an excellent quality of life for professionals and families.

Application Process

Interested candidates should attach a CV, a 2–3 page research plan, and contact information for three references. Applications will be reviewed on a rolling basis. For additional information, contact Nathan Gohlke, Faculty Recruiter, at Nathan.Gohlke@cchmc.org

For more information, please visit the Cancer and Blood Diseases Institute website at https://www.cincinnatichildrens.org/institute/cancer-blood.

Job Qualifications

• M.D., M.D/PhD, or equivalent degree
• Current active medical license issued by the State of Ohio or eligible for license
• Appropriate medical credentialing through the Medical Staff Services offices
• Completion of all required pre-employment activities
• Assistant or Associate Professor appointment or eligibility required
• Generally, requires a minimum of five years of service at the Assistant Professor rank
• Preferred: Board certification

As CCHMC continues to grow its regional, national, and international presence, clinicians may be asked to work at locations outside of the Burnet Campus.

Cincinnati Children's is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status.