Open Rank Laboratory Sciences Professional (Entry – Intermediate) – Cardiology Research

Job Summary

Our laboratory is truly translational. By leveraging biobanked human samples, we employ numerous mouse models to dissect heart transplant rejection. We have a microsurgeon to perform heart transplants in mice, a rare opportunity to work with this model system. Our system has direct translatability to patient care. Our lab works with cutting-edge technologies and has been and will continue to be highly prolific in its publication record. As a member of the lab, you will work alongside a physician-scientist (PI) that is eager and excited to teach and help you advance your career as you learn new skills, gather knowledge, and function as an essential member of the team. We will tailor your experience to your comfort level but anticipate that you will ultimately design and carry out experiments independently.

Key Responsibilities

• Mouse husbandry and genotyping of complex strain combinations (congenic, lineage tracing, genetic knockouts).
• Work alongside surgeon to learn how to assess transplant survival.
• Daily administration of critical experimental drugs or placebo.
• Heart transplant readouts will include flow cytometry, single cell RNA sequencing, histology, cytotoxicity assays, and immunofluorescence.
• You will work with the PI and a team of collaborators in an open, enthusiastic, and exciting environment.

Work Location

Onsite – this role is expected to work onsite and is located in Aurora, Colorado