"PhD in Design of AI for Closed Loop AI-driven Protein Binder Design - DTU Compute"

PhD Position: AI-driven closed-loop design & optimization of biologics

Institution: Technical University of Denmark (DTU) & Novo Nordisk

Location: Matematiktorvet, Kgs. Lyngby, Denmark

Job ID: 5276

Job category: PhD

Posting date: 27/05/2025, 20:55

Apply before: 19/06/2025, 05:59

Employment period: 3 years

Research focus:

• Development of AI models for closed-loop design of molecular binders (e.g., proteins/antibodies).
• Integration of generative AI and molecular predictors for multi-parameter optimization.
• Investigation of sequence-structure-function molecular representation spaces to support efficient AI exploration.
• Biasing generative models toward desired properties such as developability and expression.
• Validation and iterative improvement of closed-loop design systems based on experimental data.

Responsibilities:

• Propose and implement AI and optimization algorithms for binder design.
• Coordinate computational activities within a cross-disciplinary team involving automation and biotech.
• Test and refine AI-driven closed-loop systems on new molecular scaffolds.
• Mentor MSc students and collaborate with other postdocs and PhDs.

Required qualifications:

• Master’s degree (2 years, 120 ECTS or equivalent) in relevant fields.
• Experience with machine learning, generative AI models, and molecular design.
• Ability to work in cross-disciplinary research collaborations.
• Interest in mentoring and teamwork.

Collaboration & environment:

• Joint research between DTU Compute (AI/ML focus) and Novo Nordisk (life sciences).
• Access to expert supervisors from both DTU and Novo Nordisk.
• Opportunities for conference participation and networking in a vibrant international environment.
• The project is anchored in DALSA – DTU’s interdisciplinary center for life sciences and automation.

Application materials:

• Motivational cover letter
• Curriculum vitae
• Grade transcripts and diplomas (BSc/MSc) in English, including grading scale explanation

Submit as one PDF via the online application system.

Contact & further info:

• Contact person: Associate Professor Line Clemmensen (lkhc@dtu.dk)
• DTU Compute website: www.compute.dtu.dk
• Info for international applicants: DTU – Moving to Denmark