PhD position - development of the midbrain dopamine system

A PhD position for a period of 4 years on the development of the midbrain dopamine system using innovative mouse models and advanced microscopy. Terms of employment in accordance with the CAO hospitals and UMCU salary scales. Deadline 8 Nov ’25

Job description

You will work on your own project, supported by technicians and surrounded by colleagues that work with similar and other technologies. The project focuses on disentangling how dopaminergic neurons in the midbrain connect to other parts of the brain and how these connections change in disease. These aspects are important in disorders such as Parkinson’s disease and various psychiatric disorders. It is a full-time position, which will lead to a PhD thesis. Knowledge of neuroscience and experience with mouse handling are required. Familiarity with microscopy and/or molecular or cell biological techniques are strengths. The candidate needs to have good writing and presenting skills (in English).

Requirements

We seek a highly motivated and experienced PhD candidate with strong expertise in molecular and/or cellular neurobiology. It is essential that the applicant is able and interested in working in a unique multidisciplinary team with researchers from several universities involved in this project. Knowledge of neuroscience and experience with rodent handling are required. Familiarity with molecular, cellular or microscopy techniques are strengths. The candidate needs to be proficient in English.

For additional information, please contact prof. dr. R.J. Pasterkamp.

Conditions of employment

The maximum salary for this position (36 - 36 hours) is € 3.108,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

Department

The research group of Jeroen Pasterkamp studies the mechanisms underlying neural circuit development and disease using a wide variety of techniques and approaches (www.jeroenpasterkamplab.com). The group is part of the Department of Translational Neuroscience, which is a preclinical research department within the Division Neuroscience of the University Medical Center Utrecht. The research mission of the Department of Translational Neuroscience is to discover and delineate mechanisms and processes which are fundamental to the development of neural systems and to the control of behavior, and to translate these to pathogenesis and disease models. The unique advantage of this department of Neuroscience is its embedding in the clinical environment of UMCU and its multidisciplinary character. The Department’s toolkit includes light sheet microscopy, optogenetics, electrophysiology, an animal facility, viral vector generation, stem cell modelling, and more.

Additional information

Contact our colleague: Marie Hagen 088 756 88 91 m.hagen-3@umcutrecht.nl

Werken bij UMC Utrecht

Werken in het UMC Utrecht betekent werken op het snijvlak van onderzoek, onderwijs, zorg en techniek. In onze academische setting leren en innoveren we continu en zijn nieuwe ontwikkelingen altijd binnen handbereik. Lees meer over UMCU