New Perspectives in CNG Channel Research: Mechanistic Insights and Emerging Therapeutic Strategies for Retinal Degeneration

PhD Position (m/f/d) in Ion Channel Physiology and Retinal Research

This project centers on cyclic nucleotide-gated (CNG) channels in retinal photoreceptors. These channels are essential for visual signal transduction and play a pivotal role in disorders such as retinitis pigmentosa (RP) and achromatopsia (ACHM). The aim is to develop selective pharmacological strategies targeting rod- and cone-specific CNG channel isoforms and to elucidate the underlying molecular mechanisms. The PhD position is funded through a PRO RETINA Foundation fellowship.

Your Responsibilities:

Perform electrophysiological recordings (e.g., patch-clamp) on heterologously expressed channels in Xenopus oocytes; analyze novel cGMP analogs and allosteric modulators
Investigate ligand binding to retinal CNG channels to clarify the mechanisms driving isoform-specific channel activation and regulation
Integrate experimental findings with computational approaches (molecular docking, molecular dynamics simulations); conduct systematic analysis and interpretation of electrophysiological and molecular data
Prepare manuscripts and present results at scientific conferences

Your Profile:

Master’s degree in Biology, Biochemistry, Pharmacy, Biophysics, or a related discipline
Preferably initial experience with electrophysiological techniques (e.g., patch-clamp), cell/molecular biology methods, or molecular docking and MD simulations
Basic knowledge of ion channel physiology is an advantage
Highly motivated, well-organized, and curious mindset
Strong communication and teamwork skills
Excellent written and spoken English skills; good working knowledge of German is an advantage
Solid computer skills
Willingness to travel for project-related meetings and conferences

We Offer:

An innovative doctoral project in translational retinal research
Modern laboratory facilities and an academically stimulating environment
Intensive scientific supervision and opportunities for publication
PRO RETINA Foundation PhD fellowship

Benefits

secure employment / job
free continuing education
company pension
30 vacation days
health services
employee discounts
family-friendly measure
assistance in apartment
company events
cafeteria
Company-sponsored daycare

Application:

Please submit your application documents (cover letter, CV, certificates, list of publications and a one-page summary of previous scientific work) in electronic form.

Funding is provided through a doctoral fellowship from the PRO RETINA Foundation. It is expressly noted that no contract of employment but rather a visiting scholar agreement will be signed with the institution issuing the fellowship. A letter of acceptance for the doctoral fellowship will be signed directly between the PRO RETINA Foundation and the successful applicant.

Contact:

PD Dr. med. habil. Vasilica Nache

Scientific Staff

06341 9-397668

Reference number: 130/2026

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PhD Position (m/f/d) in Ion Channel Physiology and Retinal Research

Ernst-Abbe-Hochschule Jena

Am Klinikum 1, 07747 Jena, Germany

New Perspectives in CNG Channel Research: Mechanistic Insights and Emerging Therapeutic Strategies for Retinal Degeneration