PhD Position: Mitochondrial Dynamics as a Regulator of Macrophage Function and Atherosclerosis

(R1) Positions: PhD Positions Application Deadline: 31 Dec 2026 - 17:00 (Europe/Paris) Country: France Type of Contract: Temporary Job Status: Full-time Hours Per Week: 38h30 Offer Starting Date: 1 May 2027 Is the job funded through the EU Research Framework Programme?: Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?: No Offer Description Research project and scientific background Macrophages play a central role in the development and progression of atherosclerosis. Their ability to adapt their metabolism and functional properties in response to signals from their microenvironment is a key determinant of vascular inflammation and atherosclerotic plaque progression. Beyond their well-established role in cellular energy production, mitochondria are dynamic organelles involved in the regulation of cellular metabolism, inflammatory signaling and macrophage functions. MIRO1, a protein involved in mitochondrial transport and dynamics, may play a critical role in coordinating these processes. The aim of this PhD project is to investigate the role of MIRO1 in the regulation of mitochondrial dynamics, macrophage metabolism and function, and to determine the impact of these mechanisms on atherosclerosis development and progression. Particular attention will be paid to the interplay between mitochondrial dynamics, metabolic reprogramming and macrophage functions, as well as to the potential contribution of macrophages to circulating mitochondrial homeostasis. Where to apply E-mail: coraline.borowczyk@univ-cotedazur.fr Requirements Research Field: Biological sciences » Biology Education Level: Master Degree or equivalent Skills/Qualifications Required qualifications: Master's degree (MSc or equivalent) in Biology, Immunology, Cell Biology, Physiology or a related field. Strong interest in cellular biology, immunology, metabolism and cardiovascular diseases. Good knowledge of molecular and cellular biology. Scientific rigour, critical thinking and ability to work both independently and as part of a team. Animal experimentation training: Prior training and certification in laboratory animal science (in accordance with European and national regulations) is strongly preferred and will be considered a major asset, given the extensive use of mouse models throughout the project. Previous hands-on experience working with mice is highly desirable. Additional skills considered an advantage: Previous experience with mouse models, particularly genetically modified mice or experimental models of atherosclerosis. Hands-on experience in macrophage biology, especially isolation and culture of bone marrow-derived macrophages (BMDMs). Experience in flow cytometry, microscopy or mitochondrial metabolic analysis (Seahorse). Previous experience in immunology or cardiovascular research. Specific Requirements Personal skills We are looking for a highly motivated, curious and enthusiastic candidate with a strong interest in experimental research. The candidate should demonstrate good organizational skills, attention to detail, scientific curiosity and the ability to analyze and interpret experimental data. Good communication skills and the ability to work collaboratively in an international and multidisciplinary research environment are also expected. Languages: ENGLISH Level: Excellent Languages: FRENCH Level: Basic Research Field: Biological sciences » Biology Years of Research Experience: 1 - 4 Additional Information Benefits 46900 euros per year taxes included. Mandatory group health insurance with the employer covering 50% of the basic plan and 50% of optional coverage, up to a maximum of €5. Optional group retirement plan with the employer contributing €7 toward the basic plan. Partial reimbursement of public transportation costs Company cafeteria with employer contribution Eligibility criteria Master's degree (MSc or equivalent) in Biology, Immunology, Cell Biology, Physiology or a related field. Selection process Candidates should send a curriculum vitae with publication list, a short summary of research achievements, a motivation letter and the names and email addresses of at least two references Additional comments The PhD candidate will join a research team investigating the interplay between immunity, metabolism and cardiovascular diseases. The candidate will benefit from a multidisciplinary scientific environment and will be involved in laboratory meetings, seminars, scientific presentations and interactions with national and international collaborators. Website for additional job details: https://www.c3m-nice.fr/ Work Location(s) Number of offers available: 1 Company/Institute: Inserm U1065 Country: France State/Province: AM City: Nice Postal Code: 06204 Street: 151 route de saint antoine de ginestière Contact State/Province: BP2 3194 City: Nice Website: https://www.c3m-nice.fr/ Street: Bâtiment Archimed, 151 route de Ginestière Postal Code: 06204 E-Mail: coraline.borowczyk@univ-cotedazur.fr