PhD Studentship: Development of new antibacterial compounds in the fight against microbial resistance

University of East Anglia - School of Chemistry, Pharmacy & Pharmacology

Placed On: 16th October 2025

Closes: 2nd December 2025

Reference: SEARCEY_U26DTP

Primary supervisor - Prof Mark Searcey

Antibiotic resistance is a threat to our future. The proliferation of multi-drug resistant bacteria as a result of our overuse of antibiotics means that, one day, even simple surgeries may go back to being prone to deadly infections. We desperately need new antibiotics and to do this we need new targets. DNA is at the centre of all life and we all know it as the double stranded DNA structure but it can also adopt other shapes. One of these is the four way junction (4WJ) and the presence of extended sequences in the bacterial genome called “inverted repeats” suggests that this may be a good target for new antibacterial agents that stabilise or disrupt its formation.

To date, their has been very little work carried out on the formation of 4WJ in the bacterial genome, so we aim to identify sequences that can form these structures and then show that compounds that we have designed and made can stabilise them. We will use a combination of biophysical and biochemical assays to probe these structures and solid and solution phase synthesis to generate new molecules that bind to them. We will study the effects of these compounds on bacteria, using methods developed here at UEA.

This project will develop a multidisciplinary scientist with expertise from chemical to cell biology. You will have, or expect to obtain a first class, 2(i) or equivalent Honours degree in Chemistry, Biochemistry, Pharmacology or a related area.

Informal enquiries are welcomed: Professor Mark Searcey (m.searcey@uea.ac.uk) or Dr Andrew Gates (a.gates@uea.ac.uk).

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2026 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team.

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 3,4 or 5 February 2026.

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/

Entry requirements

At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).

Mode of study

Full time

Start date

1 October 2026

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD CASE studentship with Inspiralis Limited. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2025/6 stipend rate: £20,780), and a Research Training Support Grant of £5,000pa for each year of the studentship.