PhD Studentship: ‘Shielding the Vessels from Stress’ Impact of diet in protecting cerebral and vascular physiology in humans during psychological stress

University of Birmingham - School of Sport, Exercise and Rehabilitation Sciences

Qualification Type: PhD

Location: Birmingham

Funding for: UK Students

Funding amount: Not Specified

Hours: Full Time

Placed On: 9th October 2025

Closes: 30th November 2025

Background:

The impact of diet on mental health and brain performance is a topic of growing focus and concern: diets rich in saturated fats have been associated with a significant risk for cognitive decline later in life, whilst healthier diets, rich in plant polyphenols are linked to reduced risk of dementia. Additionally, the increasing prevalence of stress in our societies is also contributing to poorer brain function: e.g. chronic stress alters functional connectivity and impairs attention and increased risk of cardiovascular disease. Importantly, unhealthy/healthy food choices stressful events might either exacerbate or protect vascular and cerebral function from the effects of mental stress.

We have shown that foods rich in flavonoids can prevent negative effects of stress on vascular function both when administered in isolation and in the context of a high-fat meal. Intake of flavonoids before physiological stress also results in higher and faster levels of cerebral oxygenation in the pre-frontal cortex and better cognitive performance in young healthy individuals. As such, flavonoid-rich goods might be used as a strategy to minimize the impact of stress on brain and mental health, as well as cardiovascular health.

Objectives:

In this project, our key objectives are to investigate whether single and habitual intake of polyphenols with the diet improve brain oxygenation and arterial function in the context of stress, leading to better cognitive performance and improved mood in middle-aged healthy adults. These data will establish whether dietary polyphenols are effective to minimize the impact of stress on mood and cognitive function, by modulating the underlying physiological responses to stress. We will also identify individuals who may benefit the most from incorporation of polyphenols into their diet during stressful periods.

Significance:

Stress is widespread in society and a risk factor for heart disease, obesity and poor mental health. This work will have implications for understanding the health impact of intake of polyphenols to build physiological resilience against and/or rescue from the negative effects of stress. Ultimately, this may impact overall diet and long-term health, and it may shape future nutritional guidelines on diet around stress.

Opportunities/Training for the student:

This is a multidisciplinary project that will provide training across a number of different areas such as: Nutrition: conducting Randomized Controlled Dietary Interventional Human Trials; Physiology: training in i) ultrasound methods to assess endothelial function and blood flow in human arteries; ii) Near-Infrared Spectroscopy to assess cerebral vascular function; Psychology: training in assessing human cognitive performance/mood; Exercise Physiology: assessing cardiorespiratory fitness (VO2max tests). The successful candidate will be part of a vibrant PhD community in the school of Sport, Exercise and Rehabilitation Sciences. They will be trained by senior researchers within our research group. The student will have the opportunity to attend scientific conferences and be part of public engagement activities around Nutrition and Health.

Person Specification:

REQUIRED: First Class Degree or 2:1 in a relevant subject area. PREFERABLE: 1) An MSc in a relevant subject area; 2) Preference will be given to candidates with experience in a research setting, particularly running human studies. Informal enquiries are very much encouraged and should be directed to Dr Catarina Rendeiro (c.rendeiro@bham.ac.uk).

To apply, click the 'Apply' button above. Apply to programme 0355 PhD Sport & Exercise FT and select ‘Dr Catarina Rendeiro’ as main supervisor. Please submit: CV, Names and addresses of two referees, Covering letter.