Identifying mechanisms and therapeutic targets of stromal senescence in prostate cancer development

A postdoctoral research position supported by long-term NIH R37 grant funding is available in the laboratory of Marcus Ruscetti, Ph.D. to work on projects to:

Uncover heterogeneous senescent cell types and immune cell niches that promote tumor progression using single cell and spatial transcriptomic approaches.
Determine the impact of age-related senescence on prostate cancer onset and immune suppression.

These projects, and my laboratory, lie at the intersection of cancer genetics and tumor immunology, and at the interface of basic science and translational medicine. Our long-term goals will be to translate our basic understanding of how senescence biology regulates critical tumor-immune interactions into the development of therapeutic strategies to treat patients with deadly pancreatic and prostate cancers.

Our lab is part of the Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Chan Medical School (UMCMS) in Worcester, MA, giving us access to a multitude of state-of-the-art core facilities, shared equipment, and a highly stimulating and interactive intellectual environment.

Qualifications:

Candidates are required to have the following credentials:

A recent Ph.D. and/or M.D. degree in Biology, or a related field, with no more than 1 year of postdoctoral experience
A 1st author publication in a peer-reviewed scholarly journal from their Ph.D. and/or M.D. research
Previous mouse experience (at least 1 year)
A prior background in cancer biology
Technical proficiency in cell culture and molecular biology techniques

Candidates with the following qualifications are encouraged to apply:

Strong self-motivation
Ability to collaborate within and outside the laboratory
Ability to plan, organize and meet deadlines
Ability to independently develop, execute, and analyze experiments
Experience in genome-editing technologies, histology, microscopy, immunology, flow cytometry, and high-throughput sequencing.

To apply, please send your cover letter (1-page limit) explaining your most significant accomplishments and how they relate to our work and CV to Dr. Marcus Ruscetti.

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University of Massachusetts - Medical School

281 Lincoln St, Worcester, MA 01605, USA

Identifying mechanisms and therapeutic targets of stromal senescence in prostate cancer development

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University of Massachusetts - Medical School

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Identifying mechanisms and therapeutic targets of stromal senescence in prostate cancer development

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University of Massachusetts - Medical School

281 Lincoln St, Worcester, MA 01605, USA

Identifying mechanisms and therapeutic targets of stromal senescence in prostate cancer development

This is a Preview Listing…

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Post Doc (0)

University of Massachusetts - Medical School

281 Lincoln St, Worcester, MA 01605, USA

Identifying mechanisms and therapeutic targets of stromal senescence in prostate cancer development

This is a Preview Listing…

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