Department of Internal Medicine is a top-tier department with world-renowned faculty and staff. With world-class research, teaching and medical practice opportunities, why not choose the University of Cincinnati College of Medicine?
The Department of Internal Medicine, Division of Hematology Oncology is recruiting for a Postdoctoral fellow to work in Dr. Sarah Skuli’s Lab.
The Skuli Lab is a basic/translational laboratory with a goal of developing new therapeutic strategies for patients with myeloid malignancies [acute myeloid leukemia (AML), myelodysplastic syndrome (MDS)], particularly those with mutations in the tumor suppressor, TP53, which currently portends a terminal prognosis. To achieve this goal, we aim to understand the molecular/cellular biology and mechanisms of therapy resistance of TP53 mutant MDS/AML with a particular focus on metabolism and the tumor microenvironment.
Essential Functions
- Follow established research protocols to perform experiments in the lab.
- Design laboratory experiments in coordination with the PI. Understand the scientific principles involved in the research and use those principles to troubleshoot and adjust the protocol as appropriate.
- Maintain accurate and detailed records of all laboratory work and experiments.
- Interpret data and judged validity of data.
- Perform statistical and graphical analysis of data.
- Operate standard laboratory equipment. Troubleshoot and correct erroneous results/problems with laboratory equipment and procedures.
- Maintains optimal protocol and assay accuracy by conducting regular quality checks. Provides appropriate safety monitoring checks as assigned.
- May assist in training other post-doctoral fellows, graduate students and junior laboratory personnel in laboratory techniques and equipment.
- Willing and able to assist in daily operations of the laboratory including organization and cleanliness.
- Maintain an active role in laboratory meetings, presentations, publications, which includes contributing material for publications, abstracts and reports.
- Be willing to perform mouse-based in vivo experiments.
Required Education
Doctoral Degree in the appropriate field or discipline, or the recognized terminal degree
Required Experience
Experience with routine wet-lab techniques including mammalian cell culture, molecular biology assays (DNA/RNA/protein extraction/quantification, PCR, qPCR, western blotting, cloning/bacterial transformation), flow cytometry/cell sorting, colorimetric/fluorometric assays, Seahorse, and basic data analysis (Excel/GraphPad).
Additional Qualifications Considered
Experience analyzing bulk and single-cell RNA sequencing data. Familiarity with multi-omics datasets, including metabolomics/lipidomics/proteomics, and use of bioinformatics or statistical tools (i.e. R, Python, Seurat, DESeq2, etc) to integrate and interpret complex datasets.
