Vacancy ID: PDS004674 Position Summary/Description: The Kelada Lab is seeking a post-doctoral research associate to join their research program on the role of gene-environment interactions with air pollution in respiratory disease. We seek to uncover mechanistic links between the genome (e.g., DNA sequence variants), epigenome (chromatin accessibility), gene expression, and air pollutant-induced airway inflammation phenotypes in a mouse model system. More specifically, our project will leverage…
genetically diverse mice from the Collaborative Cross mouse genetics reference population to identify quantitative trait loci ( QTL ) that influence response to the air pollutant ozone. In addition to QTL mapping of ozone response phenotypes, we will also analyze gene expression and chromatin accessibility in key cell types and identify expression and accessibility QTL that mediate the relationships between ozone exposure and response. We are looking for an enthusiastic post-doctoral research associate to join this project and help lead efforts to generate and analyze these datasets. The post-doctoral research associate will have the opportunity to learn from lab members and other members of the genetics, pulmonary, and toxicology research communities at UNC , which are exceptionally strong. The post-doctoral research associate will also have the opportunity to work with a strong bioinformatics team at UNC to analyze genomic data, and the research project and environment will provide ample opportunities for training in these approaches. In addition to research, the post-doctoral research associate will be actively involved with writing scientific papers and presenting talks at scientific meetings. Education and Experience: Experience with mouse models of human disease Experience with flow cytometry Candidates should be self-motivated, enthusiastic, able to work in a teamwork environment, and have strong communication skills.
