Position Summary/Description Cardiovascular disease is the leading cause of death and disability in the Western world, and blood coagulation abnormalities
contribute to the pathophysiology of nearly every disease, including cancer, infection, and autoimmune and inflammatory disorders. An NIH-funded postdoctoral position is available in the Department of Pathology and Laboratory Medicine in the laboratory of Dr. Alisa Wolberg at the University of North Carolina at Chapel Hill. The Wolberg Lab is part of UNC's internationally recognized Blood Research Center. Research in the lab focuses on cellular, biochemical, and biophysical mechanisms that regulate blood function and contribute to health and disease. The successful applicant will advance ongoing R01-funded research focused on mechanisms of hemostasis and thrombosis. Potential areas of emphasis include factor (F)XIII biology (including regulation of FXIII-A and FXIII-B subunits, roles in venous thrombosis and thrombus resolution, and therapeutic targeting strategies); fibrin(ogen) degradation and the cellular and enzymatic drivers of thrombus resolution beyond plasminogen; and cellular and plasma mediators of FXI biology that influence bleeding risk. Additional opportunities exist in women's health and blood disorders and mechanisms contributing to pulmonary embolism. Projects will be tailored to the fellow's expertise, with the expectation that the postdoc will initially contribute to established research efforts and, over time, develop an independent line of investigation leading to future fellowship or career development funding. Candidates with experience in biochemistry or enzymology, cell biology (including tissue culture), histology, mouse models of thrombosis and hemostasis, and/or bioinformatics are encouraged to apply. The Wolberg Lab provides a highly supportive, team-oriented mentoring environment with strong emphasis on professional development, grant writing, and opportunities to mentor trainees, while fostering independence and ownership of scientific direction. Education and Experience Experience in blood coagulation research is strongly preferred but not required. Candidates with experience in biochemistry or enzymology, cell biology including tissue culture, histology, mouse models of thrombosis and hemostasis, and/or bioinformatics are encouraged to apply.
