Job ID: 376342
About the Job
Position Summary: The Neuromodulation Research Center (NMRC), at the University of Minnesota, seeks a postdoctoral associate to study the pathophysiology of Parkinson's disease (PD), in a progressive, preclinical, MPTP rhesus macaque model of disease progression. In particular, we are looking for candidates with interest and experience with high density recording approaches, building on recent work in our lab establishing acute and semi-chronic Neuropixel implantation approaches targeting basal ganglia, thalamus and cortex. Neural recordings are acquired across the basal ganglia thalamo-cortical circuit to examine changes in cell population dynamics, oscillatory activity, and connectivity as motor signs develop and become more severe, and as they improve with treatment conditions. These studies aim to provide the rationale for development of neuromodulatory approaches designed to reshape network activity.
Under the supervision of Luke Johnson, PhD and Jerrold Vitek, MD PhD, the associate will work collaboratively within the NMRC on an existing project supporting the collection and analysis of large-scale electrophysiological data sets. Trainees will also have opportunities for clinical exposure through our robust deep brain stimulation and movement disorders clinical research program. Candidates may refer to the below papers for context relating to ongoing experiments:
Duties/Responsibilities:
About the Job
Position Summary: The Neuromodulation Research Center (NMRC), at the University of Minnesota, seeks a postdoctoral associate to study the pathophysiology of Parkinson's disease (PD), in a progressive, preclinical, MPTP rhesus macaque model of disease progression. In particular, we are looking for candidates with interest and experience with high density recording approaches, building on recent work in our lab establishing acute and semi-chronic Neuropixel implantation approaches targeting basal ganglia, thalamus and cortex. Neural recordings are acquired across the basal ganglia thalamo-cortical circuit to examine changes in cell population dynamics, oscillatory activity, and connectivity as motor signs develop and become more severe, and as they improve with treatment conditions. These studies aim to provide the rationale for development of neuromodulatory approaches designed to reshape network activity.
Under the supervision of Luke Johnson, PhD and Jerrold Vitek, MD PhD, the associate will work collaboratively within the NMRC on an existing project supporting the collection and analysis of large-scale electrophysiological data sets. Trainees will also have opportunities for clinical exposure through our robust deep brain stimulation and movement disorders clinical research program. Candidates may refer to the below papers for context relating to ongoing experiments:
- Bauer et al 2023 J. Neural Eng: https://doi.org/10.1088/[contact details available in the full listing]/acd0d7
- Ning et al. 2026 bioRxiv: https://doi.org/10.64898/[contact details available in the full listing]
- Mohanty et al. 2025 PNAS: https://www.pnas.org/doi/10.1073/pnas.[contact details available in the full listing]
- Johnson et al. 2021 Movement disorders: https://doi.org/10.1002/mds.28566
Duties/Responsibilities:
- 75% Research Duties: Neural data collection, analysis; experimental and method development related to the use of Neuropixel recording probes in a preclinical paradigm. Analyze single and multi-unit activity derived from distributed brain regions to assess how neural circuits coordinate in the PD condition during a multiplicity of behaviors and conditions.