Job Information
Organisation/Company: Mossakowski Medical Research Institute, Polish Academy of Sciences
Research Field: Medical sciences » Other; Neurosciences » Neurochemistry
Researcher Profile: Recognised Researcher (R2)
Positions: Postdoc Positions
Application Deadline: 30 Sep 2026 - 23:59 (Europe/Warsaw)
Country: Poland
Type of Contract: Temporary
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Reference Number: ZKTS.110.1.2026
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The project focuses on elucidating the role of the purinergic P2X7 receptor (P2X7R) in the development of metabolic dysfunction and neurodegeneration in Parkinson’s disease. Particular attention will be paid to the mechanisms through which pathological forms of α-synuclein activate P2X7R, leading to mitochondrial dysfunction, oxidative stress, and impaired cellular metabolism. The research will employ complementary, state-of-the-art in vivo and in vitro models, including an experimental model of Parkinson’s disease induced by α-synuclein oligomers, behavioural testing, magnetic resonance imaging, primary neuronal cultures, and advanced molecular, biochemical, and imaging techniques.
The main research areas will include:
- regulation of oxidative stress and redox homeostasis;
- mitochondrial quality-control mechanisms, including mitophagy and the mitochondrial unfolded protein response (mtUPR);
- alterations in glucose metabolism and central carbon metabolism;
- molecular, morphological, and functional consequences of P2X7R activation in the brain;
- the relationship between metabolic dysfunction and the development of behavioural abnormalities in an experimental model of Parkinson’s disease.
The project integrates neurochemistry, mitochondrial biology, metabolomics, and research into the mechanisms of neurodegeneration. Its implementation will provide a deeper understanding of α-synuclein toxicity and help determine whether P2X7R may represent a novel therapeutic target in Parkinson’s disease.
Where to apply
E-mail: awilkaniec@imdik.pan.pl
Requirements
Research Field: Neurosciences » Neurochemistry
Education Level: PhD or equivalent
Skills/Qualifications
- Ph.D. in neurobiology, neuropharmacology, molecular biology, or related field (within 7 years before start of employment).
- Proven experience in animal experimentation (valid ethical approval required) and/or cell culture techniques.
- Strong publication record (JCR-indexed journals) and conference activity.
- Fluent communication and writing in English.
- Knowledge of biochemical and molecular methods; ability to perform statistical analyses.
- Motivation for scientific work, independence, good organizational skills, and the ability to work in a team.
Specific Requirements
Additional assets: experience with neurodegenerative disease models, mitochondrial biology, or international research mobility.
Languages: ENGLISH — Level: Excellent
Languages: POLISH — Level: Excellent
Research Field: Neurosciences » Neurochemistry
Years of Research Experience: 4 - 10
Additional Information
Benefits
- employment at one of the leading scientific institutions in Poland
- employment contract (full-time)
- hybrid work arrangements
- access to specialist equipment in the Institute
- additional support from the social fund (i.e. support in difficult life situations, childcare subsidies and low interest loans)
- possibility to join Employee Capital Plans (PPK)
- additional benefits such as opportunity to join a group life insurance program, medical service package, and a Multisport card on preferential terms
- work in a good team, in a nice atmosphere
- friendly work environment
Website for additional job details: https://imdik.pan.pl/
Work Location(s)
Number of offers available: 1
Company/Institute: Mossakowski Medical Research Institute, Polish Academy of Sciences
Country: Poland
State/Province: Mazovian
City: Warsaw
Contact
City: Warsaw
Website: http://imdik.pan.pl
Street: 5 Pawinskiego Street
Postal Code: 02-106
E-Mail: rekrutacja@imdik.pan.pl
This is a Preview Listing…
You must sign in to see the full job description, and to apply.
Manage / Upgrade this job to a Full Job Listing.
Find Your Best Opportunity
Tell them AcademicJobs.com sent you!