"Postdoc in Protein and Antibody Engineering in Cancer Research"

Job Summary: As a postdoctoral researcher, you will be part of a multidisciplinary team focused on selectively inhibiting TGF-β receptor signaling in a cell-type-specific manner to inhibit pro-tumorigenic effects while preserving physiological roles. This involves utilizing advanced protein engineering to discover and optimize antibody-based therapeutics, applying protein structure prediction and molecular modeling, and working with experts in molecular biology and cellular biochemistry using state-of-the-art technologies and models.

Responsibilities:

• Designing and purifying bispecific antibodies with properties aimed at cell-specific targeting.
• Applying biophysical, biochemical, and cell biological methods to study protein-protein interactions and cellular behavior.
• Using deep learning models, such as AlphaFold, to predict antibody-antigen and protein-protein interactions.
• Collaborating closely with experts in structural biology and computer-aided models for antibody design.
• Publishing research results and presenting at international meetings.
• Participating in group and departmental meetings and staying updated with developments in AI-driven antibody technology.

Qualifications and Requirements:

• A PhD in life sciences, chemical biology, pharmaceutical sciences, and/or cell biology, with knowledge of signal transduction and bioinformatic analysis (experience with statistical programming in R and Python).
• Skills in protein engineering to enhance protein binding affinity and function.
• Experience using deep learning models (e.g., AlphaFold and RosettaFold) for predicting protein-protein interactions is an advantage.
• Motivated, responsible, able to work independently and in a team, clear communication, proactive contributions, and thriving in dynamic, multidisciplinary environments.
• Good command of English, both spoken and written.

What the Employer Offers:

• Fixed-term contract for the duration of the project.
• Salary between €3,598 and €5,669 gross per month based on a full-time position (scale 10, CAO UMC).
• Opportunities for internal and external training, end-of-year bonus (8.3%), holiday allowance, sports budget, bicycle scheme, home office allowance, excellent commuting allowance, and affiliation with the ABP pension fund where 70% of the premium is paid by LUMC.
• A safe, inclusive, and equitable work environment with a focus on talent development and connected leadership.