Collaborative Research Center CRC1690 (Disease Mechanisms and Functional Restoration of Sensory and Motor Systems, https://sfb1690.uni-goettingen.de) and the newly founded Else Kröner Fresenius Center for Optogenetic Therapies (EKFZ: https://ekfz.uni-goettingen.de).
Your tasks
In-depth structural and functional characterization of optimized Channelrhodopsin variants for basic research in neuroscience and future optogenetic therapies Recombinant protein purification, Determination of protein stability (Prometheus NT. 48, NanoTemper Technologies), SDS PAGE, Blue Native PAGE Cryo-EM (Titan Krios G4, Thermo Fisher Scientific) High-throughput spinning disc confocal microscopy (CQ1, Yokogawa) Data analysis
Your qualifications
Excellent and highly motivated applicant with a strong background in the structural and functional characterization of membrane transport proteins Proficiency in structural biology and preferably knowledge in bioinformatics and/or patch clamp measurements and/or data-driven protein design Experience with basic molecular biology techniques (PCR, cloning etc.) Preferably knowledge in the characterization of microbial rhodopsins Skills in data analysis with Python Excellent organizational, interpersonal and communication skills The ability to work in an interdisciplinary and international team of researchers is required
We offer
Exciting work and collaboration in a multi-disciplinary team A highly innovative project The chance to contribute to work towards the development of future optogenetic therapies, in particular the optical cochlear implant
We look forward to receiving your application!
The University Medical Center Göttingen (UMG) unites the Medical Faculty of the Georg-August University and the University Hospital in an integration model. With around 9,700 employees, the UMG and its subsidiaries are one of the largest employers in the region. Our clinics and institutes stand for high-quality patient care, excellent research, modern teaching and transfer of innovative technology.
Göttingen as a city of science is located in the center of Germany and the University Medical Center Göttingen is integrated into an attractive network of university and non-university scientific institutions.
Our goal as University Medical Center Göttingen is professional equality for all genders. We strive to equalize the gender ratio in areas where there is underrepresentation. The University Medical Center Göttingen is particularly committed to the professional participation of severely disabled people and therefore welcomes applications from severely disabled people. In the case of equal suitability, applications from severely disabled persons will be given preferential consideration in accordance with the relevant regulations. We kindly ask you to indicate a disability/equal status in your letter of application in order to safeguard your interests.
