"POSTDOC POSITION in Extracellular Vesicle Research in Cancer"

Medical Faculty of Masaryk University, Brno, Czech Republic invites excellent scientists to apply for a two-year

POSTDOC POSITION in Extracellular Vesicle Research in Cancer

Description:

The research group of prof. Michal Masařík is a biomedical laboratory dedicated to exploring the molecular mechanisms that drive cancer progression, with a particular emphasis on the tumour microenvironment (TME). The team focuses on the communication networks between cancer cells and stromal components, aiming to uncover how these interactions contribute to therapy resistance, metabolic adaptation, and cancer cell aggressiveness. Our team is actively engaged in the broader EV research community—we are members of the International Society for Extracellular Vesicles (ISEV) and co-founders of the Czech Society for Extracellular Vesicles (CzeSEV).

A key theme of our research is the study of extracellular vesicles (EVs) released by cancer-associated fibroblasts (CAFs) and cancer cells under both physiological and stress conditions, such as lysosomal dysfunction or nutrient deprivation. Our studies aim to elucidate how the protein and RNA cargo of these EVs changes in response to cellular stress and how such alterations affect the biological behaviour of recipient cells, including their metabolism, migratory capacity, and sensitivity to cell death. Through this work, we strive to clarify the role of EVs in the TME and to identify novel EV-based biomarkers reflecting key processes of tumour progression. Beyond their diagnostic value, EVs hold immense therapeutic potential. Their natural ability to deliver molecular cargo in a targeted and biocompatible manner makes them promising vehicles for drug delivery, immune modulation, and precision oncology.

The successful candidate should:

• Hold a Ph.D. or its equivalent, awarded within the past 7 years, AND have worked in research for at least 2 years of work, within the last 3 years, outside the Czech Republic (with a workload equivalent to at least 0.5 full-time employment)
• Alternatively, hold a Ph.D. diploma (or equivalent) from an international institution awarded within the past 3 years
• Demonstrate a publication record that includes a minimum of three research outputs (articles) within the past three years, surpassing the field's median standards, with at least two of them ranked in Q1 according to Web of Science.

Specific qualifications include:

• Exhibit a genuine passion for scientific exploration of complex topics
• While prior experience with EVs is beneficial, it is not a mandatory requirement
• Prior experience with Density Gradient Ultracentrifugation and other methods for EV isolation and purification is highly appreciated.
• Possessing a robust foundation in molecular biology, immunology, or biochemistry will be advantageous
• Display communication abilities, strong organizational skills, and a collaborative spirit

Include these in your application:

• A comprehensive CV detailing your publication history
• A copy of your PhD diploma
• Contact information for two referees who can provide insights into your qualifications
• A brief but substantive description of your research focus and the specific topic you intend to investigate. Justify the relevance of this research within the field.
• Submission of documents validating that you have accumulated a minimum of two full years of work experience outside the Czech Republic within the past three years, and/or proof of a Ph.D. diploma from a foreign institution.

We offer:

• Access to Core Facilities and state-of-the-art facilities, including advanced imaging and sequencing technologies
• An exceptionally competitive salary, commensurate with the applicant's skills and proficiency.
• An enticing position within a rapidly evolving university precinct.
• A range of diverse and stimulating responsibilities within an outstanding research environment.
• An initial two-year appointment.
• The opportunity to collaborate with a professional team in a comfortable work environment.
• Interaction with renowned scientists within an inspiring, globally-connected setting.
• A dedicated welcome service tailored to the needs of the successful candidate and their family.

Anticipated start date: The position is available from April 2026 or upon agreement

The submission deadline is 31st January 2026

Please submit e-application.

For more information, please contact Martina Vrablikova by e-mail vrablikova@med.muni.cz.

The assessment of applications will begin promptly upon the deadline's closure. Candidates who make the shortlist will receive invitations for interviews within one month following the application deadline.