"POSTDOC POSITION in Genetic predispositions to development of hematological malignancies"

Medical Faculty of Masaryk University, Brno, Czech Republic invites excellent scientists to apply for a two-year

POSTDOC POSITION in Genetic predispositions to development of hematological malignancies

Department: Institute of Medical Genetics and Genomics

Description:

Hematological malignancies are closely related to various types of somatic mutations in blood cells, which often accumulate during the course of the disease. Recent findings point to the increasing importance of inherited genetic predispositions that influence the development of lymphoid and myeloid leukemias and other neoplasms. They could play a causal role in the development of the disease and be related to its early onset, patient prognosis and the effect of therapy. The description of novel germline mutations as risk factors for disease progression therefore has clear clinical implications and benefits for patients and their families. The underlying biological mechanisms leading to leukemic transformation are specific for each genetic variant and should be further investigated. The most frequent and severe genetic variants predisposing to hematological malignancies will be selected from a novel genome-wide analysis of the Czech/European population analyzed within the Genome of Europe project, which is currently underway in our laboratory.

The successful candidate should:

• Hold a Ph.D. or its equivalent, awarded within the past 7 years, AND have worked in research for at least 2 years of work, within the last 3 years, outside the Czech Republic (with a workload equivalent to at least 0.5 full-time employment)
• Alternatively, hold a Ph.D. diploma (or equivalent) from an international institution awarded within the past 3 years
• Demonstrate a publication record that includes a minimum of three research outputs (articles) within the past three years, surpassing the field's median standards, with at least two of them ranked in Q1 according to Web of Science.

Specific qualifications include:

• Exhibit a genuine passion for scientific exploration and a deep-seated curiosity
• While prior experience with genomic technologies is beneficial, it is not a mandatory requirement
• Possessing a robust foundation in genetics, molecular biology, and bioinformatics will be greatly advantageous
• Display exceptional communication abilities and a collaborative spirit
• Demonstrate strong organizational skills

Include these in your application:

• A comprehensive CV detailing your publication history
• A copy of your PhD diploma
• Contact information for two referees who can provide insights into your qualifications
• A brief but substantive description of your research focus and the specific topic you intend to investigate. Justify the relevance of this research within the field.
• Submission of documents validating that you have accumulated a minimum of two full years of work experience outside the Czech Republic within the past three years, and/or proof of a Ph.D. diploma from a foreign institution.

We offer:

• Access to Core Facilities and state-of-the-art facilities, including advanced imaging and sequencing technologies
• An exceptionally competitive salary, commensurate with the applicant's skills and proficiency.
• An enticing position within a rapidly evolving university precinct.
• A range of diverse and stimulating responsibilities within an outstanding research environment.
• An initial two-year appointment.
• The opportunity to collaborate with a professional team in a comfortable work environment.
• Interaction with renowned scientists within an inspiring, globally-connected setting.
• A dedicated welcome service tailored to the needs of the successful candidate and their family.

Anticipated start date: The position is available from April 2026 or upon agreement

The submission deadline is 31st January 2026

Please submit e-application.

For more information, please contact Martina Vrablikova by e-mail vrablikova@med.muni.cz.

The assessment of applications will begin promptly upon the deadline's closure. Candidates who make the shortlist will receive invitations for interviews within one month following the application deadline.