Soft biomaterials based on polymers are systems of choice to control the interaction of structural implants, e.g.
for bone defect reconstruction, with biological systems. They have the potential to favor desired interactions, e.g. colonization by cells, as well as to prevent undesired interactions, in particular infections due to microorganisms. Yet, implant associated infections remain a major risk associated with the use of biomaterials. One of the reasons is the difficulty to detect early stages of bacterial colonization. The aim of this project is to develop a family of soft biomaterials based on synthetic polymers and biomacromolecules that show good adhesion of cells and to other materials, limit infections, and able to respond with a suitable optical signal to early stages of bacterial colonization. The candidate will develop suitable luminescence-based detection systems, integrate these within soft biomaterials developed in the laboratory and test these systems for use in reconstructive surgery. Main Activities: Conception of biomaterials based on polymers and proteins to control cell adhesion and limit infections Conception of luminescent probes for detection of infections Evaluation of biological response through cell and bacteria culture Luminescence spectroscopy and microscopy of materials Associated Activities: Generalization of luminescence-based methods to different biomaterials Development of luminescent probes for SWIR and upconversion Contract duration: 13 months Start date: 2027/01/01
