Is the Job related to staff position within a Research Infrastructure? NoOffer Description
Presentation of the project :
This project aims to revolutionize prostate cancer diagnosis by identifying in urines of patients robust and non-invasive VOC signatures specific of significant prostate cancer. You will explore the direct link between volatile chemical signatures and tumor metabolic pathways, with a specific focus on fatty acid metabolism.
Presentation of the Service / laboratory :
Dedicated analytical chemistry research laboratory and a technical platform specializing in separation techniques coupled with mass spectrometry, as well as facilities for cell culture and biological sample extraction. A stimulating research environment at the crossroads of chemistry, biology, and clinical medicine. https://www.icoa.fr/
Presentation of the missions :
Under the supervision of the analytical research leads, you will be responsible for the development and optimization of VOC sampling and analysis methods. Your tasks will include: (1) Optimization of sampling techniques: development of extraction protocols for VOCs from cell lines and urine samples using SPME or a thermal micro-extraction chamber; (2) TD/GC-MS analysis (QqQ and TOF): optimization and implementation of analytical methods for metabolomic profiling of samples; (3) Data processing: identification of candidate biomarkers (chromatogram alignment, deconvolution, normalization) and chemometric analysis; (4) Interdisciplinary collaboration: close interaction with biologists (cell culture) and clinicians to integrate chemical data into machine learning models; (5) Dissemination: writing high-impact scientific articles and presenting results at national and international conferences.
Présentation of the profile :
Education: PhD in Analytical Chemistry. Technical expertise: Advanced proficiency in mass spectrometry, chemometric tools, and data processing. Assets: Experience in gas chromatography and trace-level sampling techniques. Soft Skills: Autonomous, rigorous, and motivated to work in a multidisciplinary research environment spanning chemistry, clinical science, and biology.
Where to apply
Website: https://jobaffinity.fr/apply/9snq5vsn8p0xxf9h32
Requirements
Research Field: Biological sciences
Education Level: PhD or equivalent
Skills/Qualifications
Education: PhD in Analytical Chemistry. Technical expertise: Advanced proficiency in mass spectrometry, chemometric tools, and data processing. Assets: Experience in gas chromatography and trace-level sampling techniques. Soft Skills: Autonomous, rigorous, and motivated to work in a multidisciplinary research environment spanning chemistry, clinical science, and biology.
Languages: English
Level: Good
Work Location(s)
Number of offers available: 1
Company/Institute: Institut de Chimie Organique et Analytique (ICOA)
Country: France
City: Orléans
Postal Code: 45100
Street: Rue de Chartres
Contact
City: Orléans
Website: http://www.univ-orleans.fr/
