Postdoctoral Fellow – Host-Pathogen Interactions and Bacterial Effector Biology

The Weber Laboratory in the Department of Microbiology and Immunology at the University of Iowa is seeking a highly motivated postdoctoral scholar to investigate host-pathogen interactions and bacterial effector biology during Chlamydia trachomatis infection. Our research focuses on understanding how chlamydial effector proteins promote intracellular survival, immune evasion, and pathogenesis. Current projects examine how chlamydial inclusion membrane (Inc) proteins and secreted effectors manipulate centrosome duplication, nucleocytoplasmic transport, vesicle trafficking, and innate immune signaling during infection.

Current projects focus on defining how chlamydial effectors reprogram host cell architecture and signaling pathways, how infection disrupts centrosome homeostasis and contributes to multinucleation and chromosomal instability, and how Inc proteins coordinate interactions at the host-pathogen interface to support bacterial replication and persistence.

Research in the laboratory integrates microbiology, cell biology, immunology, biochemistry, microbial genetics, CRISPR-based engineering and screens, advanced fluorescence and live-cell microscopy, proteomics, and animal models of infection. The successful candidate will join an active and collaborative research environment with opportunities to develop independent projects, publish impactful work, present at national and international meetings, and mentor trainees.

Applicants should have a Ph.D. or M.D./Ph.D. degree with a strong background in microbiology, cell biology, molecular biology, biochemistry, or immunology. Candidates with experience in microbial genetics, microscopy, infection models, or biochemical approaches are especially encouraged to apply. The ideal candidate will have a strong publication record, excellent communication skills, and the ability to work both independently and collaboratively. Compensation will be commensurate with experience and follow current NIH guidelines.

To apply, please send a cover letter describing your research experience and interests, a CV, and contact information for three references to Dr. Mary Weber at mary-weber@uiowa.edu.

Iowa City is consistently ranked among the best places to live in the United States and offers a vibrant research and cultural environment with a low cost of living, thriving arts community, and access to outstanding outdoor recreation. Iowa City is also within driving distance of several major metropolitan areas including Chicago, Minneapolis–St. Paul, Milwaukee, St. Louis, and Omaha.

Mary M. Weber, Ph.D.
Associate Professor, Department of Microbiology and Immunology
University of Iowa
mary-weber@uiowa.edu
https://weber.lab.uiowa.edu/