The overall focus of the Charles lab is to decrease the global burden of mucosal and enteric infections of import affecting resource-poor and marginalized populations. More specifically, work in the lab is focused on furthering our understanding of host-pathogen and immune responses during human infection by V. cholerae (the cause of cholera) and Salmonella enterica serovar Typhi and Paratyphi A (the primary cause of enteric fever) and to identify immunogenic antigens or molecular signatures for…

The overall focus of the Charles lab is to decrease the global burden of mucosal and enteric infections of import affecting resource-poor and marginalized populations. More specifically, work in the lab is focused on furthering our understanding of host-pathogen and immune responses during human infection by V. cholerae (the cause of cholera) and Salmonella enterica serovar Typhi and Paratyphi A (the primary cause of enteric fever) and to identify immunogenic antigens or molecular signatures for…