Appointment Type: Postdoctoral Fellow
Department: IUSM - Medicine - Nephrology
Campus: IU School of Medicine Indianapolis
Position Summary
The Division of Nephrology at Indiana University School of Medicine is seeking a highly motivated Postdoctoral Fellow to join a multidisciplinary research program investigating the biology of uromodulin (UMOD), thick ascending limb (TAL) epithelial cells, and their roles in kidney injury and kidney stone disease.
Our laboratory studies fundamental mechanisms regulating UMOD biology, including its intracellular trafficking, processing, secretion, alternative splicing, and cellular functions during kidney injury and repair. A major focus of the laboratory is understanding how alterations in UMOD biology influence TAL cell function, mitochondrial metabolism, acute kidney injury (AKI), progression from AKI to chronic kidney disease, and nephrolithiasis.
Current projects include:
Research and Career Development Environment
The fellow will join a collaborative kidney research environment at Indiana University School of Medicine with access to expertise and infrastructure in renal physiology, molecular and cellular biology, animal models of kidney disease, advanced microscopy, spatial transcriptomics, spatial proteomics, and translational human kidney research.
An important objective of the position is career development toward scientific independence. The fellow will be encouraged to develop independent hypotheses within the broader research program, lead manuscripts, present at national and international meetings, participate in grant writing, and develop an independent scientific niche over the course of the fellowship.
The Division's research activities are led by world-renowned faculty members developing innovative protocols and driving the standard of care for diseases related to Nephrology.
The search committee will begin evaluating applications as they are received and applications will continue to be reviewed until positions are filled.
About the School and Department: The Indiana University School of Medicine https://medicine.iu.edu/ is the largest medical school in the US and is annually ranked among the top medical schools in the US by US News & World Report. Please visit https://medicine.iu.edu/internal-medicine for additional information about the Department of Medicine.
About the Campus: To learn more about the Indiana University-Indianapolis campus, please visit: https://indianapolis.iu.edu/about/
About Indianapolis: Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the nation's largest concentrations of health sciences companies. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city and surrounding suburbs enjoy leading educational systems and top-ranked universities paired with a diverse population. Indianapolis International Airport is a top-ranked international airport that has been named "Best Airport in North America" by Airports Council International for many years. For additional information on life inIndy: https://faculty.medicine.iu.edu/relocation
IU School of Medicine is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.
Basic Qualifications
The candidate should have expertise in molecular and cell biology or related field. The candidate should be highly motivated and work both independently and within a team. The position requires excellent interpersonal and communication skills which will facilitate training and career development.
Qualifications Terminal degree required. Applicants should have a PhD, MD, MD/PhD, or equivalent doctoral degree in cell biology, molecular biology, physiology, biochemistry, nephrology, or a related biomedical field. Candidates should be highly motivated, scientifically curious, and able to work both independently and collaboratively.
Experience in one or more of the following areas is desirable:
Department Contact for Questions
Please contact Tara Wilson at [contact details available in the full listing] for any questions related to this posting.
Posting Number
IUSM-[contact details available in the full listing]
Department: IUSM - Medicine - Nephrology
Campus: IU School of Medicine Indianapolis
Position Summary
The Division of Nephrology at Indiana University School of Medicine is seeking a highly motivated Postdoctoral Fellow to join a multidisciplinary research program investigating the biology of uromodulin (UMOD), thick ascending limb (TAL) epithelial cells, and their roles in kidney injury and kidney stone disease.
Our laboratory studies fundamental mechanisms regulating UMOD biology, including its intracellular trafficking, processing, secretion, alternative splicing, and cellular functions during kidney injury and repair. A major focus of the laboratory is understanding how alterations in UMOD biology influence TAL cell function, mitochondrial metabolism, acute kidney injury (AKI), progression from AKI to chronic kidney disease, and nephrolithiasis.
Current projects include:
- Defining the molecular mechanisms regulating UMOD trafficking, intracellular processing, and secretion in TAL cells.
- Investigating alternative splicing of UMOD, including injury-induced UMOD isoforms with distinct intracellular localization and functions.
- Determining how UMOD regulates mitochondrial metabolism and cellular adaptation to kidney injury.
- Investigating mechanisms linking UMOD to kidney stone formation and nephrolithiasis.
- Developing therapeutic approaches that manipulate UMOD biology, including splice-modifying strategies.
- Integrating molecular and cell biology with animal models, advanced imaging, spatial biology, and human kidney tissue studies.
Research and Career Development Environment
The fellow will join a collaborative kidney research environment at Indiana University School of Medicine with access to expertise and infrastructure in renal physiology, molecular and cellular biology, animal models of kidney disease, advanced microscopy, spatial transcriptomics, spatial proteomics, and translational human kidney research.
An important objective of the position is career development toward scientific independence. The fellow will be encouraged to develop independent hypotheses within the broader research program, lead manuscripts, present at national and international meetings, participate in grant writing, and develop an independent scientific niche over the course of the fellowship.
The Division's research activities are led by world-renowned faculty members developing innovative protocols and driving the standard of care for diseases related to Nephrology.
The search committee will begin evaluating applications as they are received and applications will continue to be reviewed until positions are filled.
About the School and Department: The Indiana University School of Medicine https://medicine.iu.edu/ is the largest medical school in the US and is annually ranked among the top medical schools in the US by US News & World Report. Please visit https://medicine.iu.edu/internal-medicine for additional information about the Department of Medicine.
About the Campus: To learn more about the Indiana University-Indianapolis campus, please visit: https://indianapolis.iu.edu/about/
About Indianapolis: Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the nation's largest concentrations of health sciences companies. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city and surrounding suburbs enjoy leading educational systems and top-ranked universities paired with a diverse population. Indianapolis International Airport is a top-ranked international airport that has been named "Best Airport in North America" by Airports Council International for many years. For additional information on life inIndy: https://faculty.medicine.iu.edu/relocation
IU School of Medicine is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.
Basic Qualifications
The candidate should have expertise in molecular and cell biology or related field. The candidate should be highly motivated and work both independently and within a team. The position requires excellent interpersonal and communication skills which will facilitate training and career development.
Qualifications Terminal degree required. Applicants should have a PhD, MD, MD/PhD, or equivalent doctoral degree in cell biology, molecular biology, physiology, biochemistry, nephrology, or a related biomedical field. Candidates should be highly motivated, scientifically curious, and able to work both independently and collaboratively.
Experience in one or more of the following areas is desirable:
- Molecular and cellular biology
- Protein trafficking and intracellular organelle biology
- RNA biology, alternative splicing, or transcriptomics
- Mitochondrial biology and cellular metabolism
- Kidney physiology or epithelial transport
- Acute kidney injury or chronic kidney disease models
- Nephrolithiasis or mineral metabolism
- Mouse models and experimental surgery
- Confocal, multiplexed, or advanced fluorescence imaging
- Spatial transcriptomics, spatial proteomics, or quantitative image analysis
Department Contact for Questions
Please contact Tara Wilson at [contact details available in the full listing] for any questions related to this posting.
Posting Number
IUSM-[contact details available in the full listing]
