Postdoctoral - Pediatric Brain Tumors (Tailor Lab)

Appointment Type

Postdoctoral Fellow

Department

IUSM - Neurological Surgery

Position Summary

A full-time Post-Doctoral Research position is available in the Department of Neurological Surgery. The candidate will assist the principal investigator in conducting research on pediatric brain tumors, primarily pineoblastoma. Our research is focused on examining the molecular mechanisms of tumor progression and the identification of novel drug targets using genomic and proteomic techniques as well as human stem cell models. The candidate must be comfortable with advanced molecular biology techniques and bioinformatics. We are seeking a self-directed, self-motivated, curious, creative, and well-organized candidate with experience in stem cell and cancer biology, molecular biology, next-generation sequencing techniques, bioinformatics, proteomic analysis, and animal handling to join our team.

Job Summary

Primary Duties and Responsibilities:

• Bioinformatic analysis of single cell and next-generation RNA sequencing, and proteomic analysis of kinome data.
• Advanced molecular biology techniques including gene editing (CRISPR), plasmid design and production, bacterial culture, plasmid purification, and related analyses.
• Molecular biology and biochemical analyses including Western blotting, protein assays, PCR, RT-PCR, DNA and RNA purification and sequencing.
• Animal (mouse) handling/manipulations: Perform surgeries/implantations (will train), biopsies, bioluminescence imaging, and drug administration.
• Extensive tissue culture required.
• Flow cytometry and microscopy; phenotypic analysis and imaging.
• Keep organized analytical data of performed experiments and expected to report findings at lab meetings.
• Acts as a liaison/mentor to technicians, students and other laboratory personnel for training.
• Responsible for the initiation, monitoring, completion, and reporting of complex and intricate laboratory experiments. Organize and implement data review and analysis.
• Collaborate with other University Faculty and labs for common goals.
• Expected to keep current on relevant literature to identify suitable direction, new techniques, procedures and methods.
• Expected to submit research to national, professional meetings for possible presentations.
• Expected to publish in peer reviewed journals.