Description

Applications are invited for postdoctoral positions in the laboratory of Dr. Daniel J. Rader, Departments of Medicine and Genetics at the Perelman School of Medicine (PSOM) of the University of Pennsylvania.

The Rader lab is a multidisciplinary research environment focused on leveraging human gene discovery to elucidate the biology and molecular physiology of genes and pathways that influence plasma lipoprotein metabolism as well as the role of lipids in cardiometabolic traits and diseases (including atherosclerosis and metabolic dysfunction-associated steatotic liver disease or MASLD) and neurodegeneration/Alzheimer’s disease.

The lab integrates computational genomics, fundamental molecular investigation in cell and animal model systems, and targeted deep phenotyping in human subjects to establish molecular mechanisms, clinical relevance and accelerate translation of research insights to potential treatment of human cardiometabolic disorders.

Research Approaches

The research incorporates:

1. Computational multi-omics to identify genes and pathways of interest.
2. Human induced pluripotent stem cell (iPSC)-derived cell types to examine impact on hallmarks or biomarkers of phenotype and/or disease.
3. Mouse model systems including germline and somatic gene manipulation.
4. Use of natural genetic variants to elucidate protein structure-function relationships.
5. Recall-by-genotype studies in humans for deep phenotyping to inform genotype-phenotype relationships.

Preferred Research Backgrounds

We particularly encourage inquiries from:

• Bench scientists with some background in lipid metabolism.
• Dry lab scientists with experience in bioinformatics and high-throughput genomics, metabolomics and/or proteomics technologies.