Postdoctoral Position: Red Blood Cell Immunobiology

The Mangalmurti Laboratory, in the Department of Medicine's Divison of Pulmonary, Allergy and Critical Care, invites applications for a postdoctoral position focused on evaluating red blood cells (RBCs) as a novel liquid biopsy platform for cancer detection and disease monitoring. This industry-sponsored project will investigate the biological basis, analytical performance, and translational potential of RBC-associated tumor DNA (rtDNA) as a new substrate for precision oncology applications.

The successful candidate will lead studies integrating in vitro tumor-RBC co-culture systems, preclinical cancer models, and clinical specimens from patients with cancer to define the mechanisms of rtDNA acquisition, persistence, and detection. The project will include development and optimization of molecular assays for mutation detection, evaluation of analytical sensitivity and specificity, and assessment of the feasibility of RBC-based liquid biopsy approaches across multiple oncology indications.

Qualifications

Applicants must hold a Ph.D., M.D., or M.D./Ph.D. in cancer biology, molecular biology, genomics, bioengineering, hematology, immunology, or a related discipline. Candidates should have a strong record of scientific accomplishment and a demonstrated interest in translational cancer research, biomarker development, liquid biopsy technologies, or precision oncology.

Experience with molecular and cellular biology techniques, including PCR, digital PCR, next-generation sequencing, circulating biomarker analysis, flow cytometry, or related methodologies is desirable.

Application Instructions

Applicants should submit the following materials:

1. A cover letter describing research interests, relevant experience, and career goals
2. A curriculum vitae (CV)
3. Contact information for three references