Our lab is equipped with cutting-edge genomics, metabolomics, molecular biology, and bioinformatics platforms, including in-house LC-MS and GS-MS-based metabolomic platforms, illumina sequencer, 10xGenomics single-cell technologies, and flow cytometry. Our team brings together enthusiastic scientists with diverse backgrounds and provides a wide range of perspectives in a multi-disciplinary and collaborative team setting. Since establishing the laboratory, our team has published a series of impactful papers including:
- Development of CRISPR CAPTURE for in situ analysis of chromatin interactions (Cell 170:1028)
- Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation (Cancer Discovery 9:1228)
- Epigenetic silencing of LINE-1 retrotransposons is an AML-selective dependency (Nature Genetics 53:672)
- Mechanisms driving resistance to IDH-targeting therapies in myeloid leukemia (Cancer Discovery 13:170)
- A glutamine metabolic switch controls normal and pathological erythropoiesis (Science 386:eadh9215)
Potential research projects:
- Identify and target metabolic and epigenetic vulnerabilities in blood cancers and therapy response
- Develop non-coding RNA-based nucleic acid therapeutics for inherited blood disoders
- Target disease-associated metabolic processes using pharmacologic and genetic approaches
- Develop AI/ML tools for integrating metabolomics, transcriptomics, and genomics datasets across development and disease
Candidates must hold a Ph.D. and/or M.D. degree with a strong background in hematology/oncology, metabolism research, biochemistry, molecular biology, and/or a related field. The ideal candidate will exhibit independence, flexibility and creativity with a record of scientific productivity. Previous experience in metabolomics, computational biology, and/or hematology-oncology is strongly preferred.
Interested individuals should send a CV, a short summary of research interest and experience, and a list of three references to:
Jian Xu, Ph.D.
Member, St. Jude Faculty
St. Jude Children's Research Hospital
Email: [contact details available in the full listing]
