protein-protein interactions, myopeptide-based therapeutics, gene therapies, drug screening, preclinical studies, cardiac contractility and signaling in hypertrophic cardiomyopathy and heart failure, with the overarching goal of uncovering new molecular mechanisms that serve as tractable therapeutic targets to improve heart health.
The lab utilizes multiple techniques to study basic molecular mechanisms of disease from molecules all the way through to the organism, including iPSC-derived cardiomyocytes, organoids, and animal models. This includes molecular biology (RNAseq and proteomics), biochemistry, measuring cardiac function (echocardiography), pressure volume loop (cardiac slicing), isolated cardiomyocytes (IonOpt,ix) and skinned papillary and myocytes (Aurora system), h-gh resolution confocal microsc,opy and in vivo studies.
Visa sponsorship is not available for this positions.
Outstanding U of A benefits include health, dental, and vision insurance plans; life insurance and disability programs; paid vacation, sick leave, and holidays; U of A/ASU/NAU tuition reduction for the employee and qualified family members; retirement plans; access to U of A recreation and cultural activities; and more!
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Duties & Responsibilities
- Lead
research projects in close collaboration with the PI and other lab
members. - Innovate
new areas of experimental inquiry. - Advance
technical aspects of experimental approaches and mechanistic understanding
of biological problems. - Mentor
junior lab members and contribute to a productive scientific environment. - Maintain
detailed records and disseminate research findings in meetings and as
manuscripts in scientific journals. - Apply
for independent funding and contribute to grant proposals submitted by the
PI. - There
may be additional duties assigned as it relates to this position.
Knowledge, Skills, and Abilities:
- Ability
to work efficiently, effectively and semi-independently on research
projects within an area of specialization. - Thorough
technical and theoretical knowledge of research project and the
objectives. - Demonstrated
aptitude to perform experimental protocols and procedures, including
detailed data collection and analysis. - Ability
to communicate (grant and manuscript writing, oral presentation)
effectively. - Ability to present research finding on a regular
basis to peers within the center and at national and international meetings.
Minimum Qualifications
- PhD
in a related field, such as cardiovascular biology, with physiology,
biochemistry, molecular and cellular biology.
Preferred Qualifications
- At least two first author publications.
- Experience in cardiac physiology, molecular and cellular assays, and rodent models of disease.
- 0-1 years postdoctoral experience preferred, although more experienced candidates with desired expertise will be considered.
FLSA: Exempt
Full Time/Part Time: Full Time
Number of Hours Worked per Week: 40
Job FTE: 1.0
Work Calendar: Fiscal
Job Category: Research
Benefits Eligible: Yes - Full Benefits
Rate of Pay: NIH salary guidelines, Depends on Experience
Compensation Type: salary at 1.0 full-time equivalency (FTE)
Type of criminal background check required: Name-based criminal background check (non-security sensitive)
Number of Vacancies: 1
Contact Information for Candidates
Dr. Sakthivel Sadayappan, sadayappan@arizona.edu
Open Until Filled: Yes
Documents Needed to Apply: Curriculum Vitae (CV) and Cover Letter
Special Instructions to Applicant
Application: The online application should be completed in its entirety. Blank or missed information may be considered an incomplete submission.
Cover Letter: Should clearly indicate how your skills and professional employment experience meet the Minimum and the Preferred qualifications (if applicable).
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