About the Role
We are seeking an ambitious & highly motivated Postdoctoral Research Associate to join a newly funded British Heart Foundation (BHF) research project investigating metabolic mechanisms linking intermittent hypoxia to cardiovascular dysfunction in obstructive sleep apnoea (OSA), a common clinical condition associated with major cardiovascular risk.
The project combines in vivo cardiovascular phenotyping in murine models with integrated molecular, cellular, genetic, and metabolic approaches to investigate how hypoxic stress alters cardiometabolic regulation. Experimental work will include advanced physiological phenotyping, mechanistic studies of metabolic signalling pathways, and translationally relevant models of intermittent hypoxia.
The successful candidate will join the laboratory of Dr Gabor Czibik at the William Harvey Research Institute (WHRI), Queen Mary University of London, and become part of a dynamic and collaborative multidisciplinary research environment spanning cardiovascular physiology, metabolism, endocrinology, and hypoxia biology.
This position offers an excellent opportunity for a motivated early-career researcher seeking to develop expertise in integrative physiology and translational cardiometabolic research.
About You
Applicants should hold a PhD (or be close to completion) in cardiovascular physiology, experimental cardiology, biomedical science, metabolism, or a related discipline.
The successful candidate will have experience in in vivo murine physiology and a strong interest in cardiovascular and metabolic research. Experience with cardiovascular phenotyping techniques such as echocardiography, haemodynamic measurements, or related physiological approaches is essential.
Experience in molecular biology, histology, biochemical analysis, hypoxia biology, metabolism, or integrative physiology would be advantageous. Candidates should demonstrate strong experimental, analytical, and organisational skills, together with the ability to work both independently and collaboratively within a multidisciplinary research environment.
We are particularly interested in candidates who are intellectually curious, motivated to develop new experimental approaches, and enthusiastic about translational cardiovascular research.
About the School/Department/Institute/Project
The William Harvey Research Institute is one of the UK’s leading centres for cardiovascular, endocrine, and metabolic research, with internationally recognised programmes spanning fundamental discovery science through to clinical translation.
The PHÆDRA project aims to uncover previously unrecognised metabolic mechanisms linking intermittent hypoxia to cardiovascular disease. The work addresses an important unmet clinical need, as current therapies for OSA improve respiratory symptoms but do not reliably prevent cardiovascular complications.
About Queen Mary
At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.
Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.
We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.
Benefits
We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities.
Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.
£38,419 to £46,618 per annum.