Position Summary/Description:
The Postdoctoral Research Associate will focus on muco-obstructive lung disease, including the biology and physiology of airway secretions in general and mucus in particular, and how the properties of these secretions relate to mucus transport in the mammalian lung in health and disease. Core research activities will involve in vivo and in vitro measurement of mucus biophysical properties, coupled with measurements of mucus transport, which may include particle transport assays and optical…
coherence tomography. Related work may include single-cell RNA/ATAC sequencing, RNA in situ hybridization, and CRISPR/Cas9-based gene editing in primary human large- and small-airway epithelial cells. The Postdoctoral Research Associate may also contribute to studies of bronchiectasis, cystic fibrosis, asthma, and COPD, using new immune-epithelial-mesenchymal co-culture models; perturbation approaches to define region-specific transcriptional regulation of epithelial homeostasis; characterization of sputum and mucus properties from human samples; and spatial transcriptomics/proteomics and morphological analysis of human lung tissue.
Education and Experience:
Preferred qualifications include:
- An understanding of pulmonary physiology in health and disease as well as pulmonary medicine
- Experience interfacing with subjects with normal human pulmonary physiology and subjects with diseases that can be characterized as muco-obstructive, i.e. COPD, asthma or CF
- Excellent understanding of general medical and scientific, skills and abilities to apply expertise to novel experimental systems
- Excellent interpersonal and communication skills.
