Dr. Riccardo Mezzadra Dissecting the Interplay Between Senescence and Antitumor Immunity in Liver Cancer Contract term : Fixed up to
6 years, subject to successful review at Year 3 About us The CRUK Scotland Institute is a cancer research institute, situated in Glasgow with approximately 250 researchers split across 30 research groups consisting of PIs, postdoctoral scientists, PhD students and scientific officers. It is one of Europe's leading cancer research centres, supporting cutting-edge work into the molecular mechanisms of cancer development. As well as core support from Cancer Research UK, the Institute also receives an additional third of its total income from external grants and industry collaborations. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis. Project Outline Join the newly established laboratory of Dr Riccardo Mezzadra, launching in March 2027 and funded through a CRUK Career Development Fellowship. Dr Mezzadra's research focuses on understanding how conventional cancer therapies shape anti-tumour immune responses, with particular expertise in T cell immunology, tumour-immune interactions, and the use of advanced in vivo models to investigate mechanisms of anti-cancer immunity. This is an exciting opportunity to become the first postdoctoral scientist in a growing research group investigating how conventional cancer therapies influence anti-tumour immunity and responses to immunotherapy. Working closely with the Group Leader, you will lead innovative studies combining in vivo cancer models, tumour and immune microenvironment profiling, genetic perturbation approaches, and functional screening strategies to address fundamental questions in cancer immunology. Key Responsibilities Design and deliver research using in vivo mouse models of cancer, including therapeutic interventions and tissue collection. Investigate how cancer therapies influence tumour-immune interactions through in vivo and ex vivo experimental approaches. Apply tumour and immune profiling techniques, including flow cytometry and spatial analyses, to characterise treatment responses. Develop and utilise genetic perturbation and screening approaches to identify factors that regulate anti-tumour immunity. Establish new experimental protocols and research workflows within a newly formed laboratory. Collaborate with multidisciplinary teams across the Institute and external partners. Publish research findings in leading journals and present at national and international conferences. Contribute to the supervision and development of students and junior researchers. About You Essential PhD (completed or near completion) in tumour immunology, cancer biology, biomedical sciences, or a related discipline. Experience in laboratory-based research relevant to cancer biology and/or immunology. Ability to work independently and drive research projects forward. Strong communication and collaborative working skills. Desirable Experience working with in vivo mouse models of cancer. Expertise in immunology. Knowledge of molecular biology, genetic manipulation, or functional screening approaches. For informal enquiries, please email Dr Riccardo Mezzadra at riccardo.mezzadra@glasgow.ac.uk All applications must be made via our website by clicking on the ' Apply ' button above. Closing date: 4 th December 2026 £39,253 to £45,505 subject to experience, plus relocation allowance and visa costs if required
