Applications are encouraged from highly motivated scientists with expertise and/or interest in in vivo electrophysiology, modern circuit interrogation approaches, and/or mouse behavior. Extensive training and mentorship will also be provided. Applicants should have a PhD in the life sciences, physics, or biomedical engineering, preferably with research experience in neuroscience. If interested, please submit a brief cover letter describing your career path and future goals, a resume and contact information for two to three references to [contact details available in the full listing].
The primary aims of our work are to understand: 1) how basal ganglia microcircuits regulate movement, affect, and cognition; 2) which aspects of basal ganglia circuit dysfunction underly the symptomatic expression of Parkinson’s disease (PD) and Huntington’s disease (HD); and 3) why specific types of basal ganglia cells are susceptible to degeneration in PD and HD. We then use this data to inform the development of therapies that more effectively treat the symptoms and underlying causes of PD and HD. We use mouse models of PD and HD in combination with several experimental approaches including in vivo and ex vivo electrophysiology, 2-photon imaging, molecular profiling, circuit mapping, optogenetics, chemogenetics, and mouse behavior. This work is supported by the National Institute for Neurological Disorders and Stroke, Cure Huntington’s Disease Initiative Foundation, and Aligning Science Across Parkinson’s Disease.
