The Genome Institute of Singapore (GIS) is Singapore's flagship institute for the genomic sciences. The Agency for Science, Technology, and Research (A*STAR) is the parent funding body for the GIS and has a long-term commitment to advance science and develop innovative technology to further economic growth and improve lives. As one of the world's premier genomic centres, the GIS integrates genetics, genomics, high-throughput biology, and data science to gain fundamental, translational, and clinical insights into human disease and health (https://www.a-star.edu.sg/gis/).

We welcome applications at all levels, including candidates seeking their first independent Principal Investigator position (equivalent to first-time Assistant Professor at academic institutions) and qualified established leaders in their fields (at the level of Associate/Full Professor) to develop their independent research programmes in the following domains:

• AI and computational biology to leverage state-of-the-art artificial intelligence to design and implement or use generative models targeting RNA, DNA, and cellular systems, to enable novel insights into biology and human health
• Cancer Genomics and Biology to harness large-scale experimental and clinical data to advance biomarker and therapeutic target discovery, as well as advancing translational outcomes
• Precision Health and Aging to advance our current understanding of human aging in the Asian population, as well as to enable individual treatment through population-scale genome sequencing efforts in Singapore
• Technology development for unveiling new insights into the biology of DNA or RNA for translational applications. Candidates with an established track record in sequencing methodology development, genomics, functional genomics (e.g. saturation mutagenesis), and molecular engineering are highly welcome.

Principal investigators will be able to leverage GIS' strong sequencing facility, technology platforms, novel computational analytics, and outstanding biological systems to create scientific and societal impact.

Qualified candidates should have an MD, PhD, or equivalent degree in the biological, genomic, or computational sciences, and a demonstrated ability to conduct cutting-edge team-based research with a strong record of peer-reviewed publications, and external funding. Past successes in intellectual property creation will be an advantage. You must be comfortable working in a dynamic research organization. Strong communication skills and a willingness to work collaboratively in a multidisciplinary environment are critical for success. The successful candidate will drive an expansion into the indicated research areas and complement programs at GIS and synergise with ongoing larger-scale efforts at A-STAR. In particular, we welcome applications from energetic and enthusiastic candidates seeking their first independent Principal Investigator position (equivalent to first-time Assistant Professor at academic institutions).