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A*STAR Agency for Science, Technology and Research  Jobs

A*STAR Agency for Science, Technology and Research

Principal Investigators (GIS)

Closes:

787

The Genome Institute of Singapore (GIS) is Singapore's flagship institute for the genomic sciences. The Agency for Science, Technology, and Research (A*STAR) is the parent funding body for the GIS and has a long-term commitment to advance science and develop innovative technology to further economic growth and improve lives. As one of the world's premier genomic centres, the GIS integrates genetics, genomics, high-throughput biology, and data science to gain fundamental, translational, and clinical insights into human disease and health (https://www.a-star.edu.sg/gis/).

We welcome applications at all levels, including candidates seeking their first independent Principal Investigator position (equivalent to first-time Assistant Professor at academic institutions) and qualified established leaders in their fields (at the level of Associate/Full Professor) to develop their independent research programmes in the following domains:

  • AI and computational biology to leverage state-of-the-art artificial intelligence to design and implement or use generative models targeting RNA, DNA, and cellular systems, to enable novel insights into biology and human health
  • Cancer Genomics and Biology to harness large-scale experimental and clinical data to advance biomarker and therapeutic target discovery, as well as advancing translational outcomes
  • Precision Health and Aging to advance our current understanding of human aging in the Asian population, as well as to enable individual treatment through population-scale genome sequencing efforts in Singapore
  • Technology development for unveiling new insights into the biology of DNA or RNA for translational applications. Candidates with an established track record in sequencing methodology development, genomics, functional genomics (e.g. saturation mutagenesis), and molecular engineering are highly welcome.

Principal investigators will be able to leverage GIS' strong sequencing facility, technology platforms, novel computational analytics, and outstanding biological systems to create scientific and societal impact.

Qualified candidates should have an MD, PhD, or equivalent degree in the biological, genomic, or computational sciences, and a demonstrated ability to conduct cutting-edge team-based research with a strong record of peer-reviewed publications, and external funding. Past successes in intellectual property creation will be an advantage. You must be comfortable working in a dynamic research organization. Strong communication skills and a willingness to work collaboratively in a multidisciplinary environment are critical for success. The successful candidate will drive an expansion into the indicated research areas and complement programs at GIS and synergise with ongoing larger-scale efforts at A-STAR. In particular, we welcome applications from energetic and enthusiastic candidates seeking their first independent Principal Investigator position (equivalent to first-time Assistant Professor at academic institutions).

Job details

Title
Principal Investigators (GIS)
Employer
A*STAR Agency for Science, Technology and Research
Location
2 Fusionopolis Wy, #08-01 Innovis, Singapore 138634
Published
Jul 1, 2026
Closes:
Jul 30, 2026
Job type
Full time, Academic / Faculty, Biology
Field
Computational Biology

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Frequently Asked Questions

🎓What qualifications are required for Principal Investigator roles at GIS?

Applicants need an MD, PhD or equivalent in biological, genomic or computational sciences plus a strong record of peer-reviewed publications and external funding. View similar faculty positions.

🔬Which research domains are open for new Principal Investigators?

Positions are available in AI & computational biology, cancer genomics, precision health & aging and technology development for DNA/RNA systems. Explore related research opportunities.

📝How competitive is the application process for GIS Principal Investigator positions?

The role is highly competitive. Successful candidates demonstrate cutting-edge, team-based research and the ability to secure funding. See postdoctoral pathways that lead to these positions.

🌍Is visa sponsorship available for international applicants?

Yes, visa sponsorship is typically offered for qualified international candidates relocating to Singapore. Browse sponsored academic roles.

🏛️What support does GIS provide for new Principal Investigators?

New PIs gain access to world-class sequencing facilities, technology platforms and outstanding biological systems to drive impactful research. View leadership roles.
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A*STAR Agency for Science, Technology and Research  Jobs

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