"Research Area Specialist Senior"

We are looking for a talented and experienced individual for a position in a translational brain tumor research laboratory in the Department of Neurosurgery at the University of Michigan Medical School.

Using a combination of in vitro and in vivo modeling, analyses of clinical brain tumors samples and multi-omics (including single cell and spatial transcriptomics) our lab focuses on exploring the intrinsic and extrinsic tumor microenvironmental interactions mediating treatment resistance in gliomas. The projects in the laboratory will also have a strong translational component including involvement in an ongoing clinical trial.

The ideal candidate will possess extensive experience in molecular and cellular biology and will be capable of leading research projects that unravel aberrant cellular signaling mechanisms in cancer, this includes extensive in vivo modeling experience and experience in immunology. Experience in metabolomics preferred. Demonstrating the ability to work independently in the laboratory is paramount. Furthermore, you will be able to pursue innovative and exciting projects while simultaneously fostering your research career.

• Development of targeted gene modification in cell lines, co-cultures, and mouse models to study intrinsic and extrinsic mechanisms mediating tumor progression.
• Develop model systems and employ novel methodologies to elucidate the underlying mechanisms of treatment resistance in brain cancer
• Development of tools for biomarker assessment in translational brain cancer research
• Exhibit meticulous scientific rigor and attention to detail when designing and testing hypotheses, as well as analyzing data.

• PhD in a recognized field of study related to the position with laboratory experience in cancer biology.
• Experience in the use of genetically engineered cell lines
• Extensive in vivo mouse models experience; experience with immunology and/or metabolomics preferred.
• Have strong oral and written communication skills
• Have a positive, independent, and collaborative attitude suitable for working in a research laboratory
• Strong scientific curiosity and record of rigorous evidence-based publications.

Candidate will have an opportunity to be supported and co-mentored by a team of collaborative investigators.

References:

• Al-Holou WN... Rehemtulla A. Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma. Neoplasia. 2023 Feb;36:100872. doi: 10.1016/j.neo.2022.100872. Epub 2023 Jan 6. PMID: 36621024.
• Scott AJ, Mittal A, Meghdadi B, Palavalasa S, ... Lyssiotis CA*, Al-Holou WN*, Nagrath D*, Wahl DR*. Rewiring of cortical glucose metabolism fuels human brain cancer growth. Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09460-7. Epub ahead of print. PMID:40903569. (bioRxiv) (*Co-Corresponding Authors)
• Liu Y, ..., Rehemtulla A. Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy. Cancer Res. 2019 Jun 1;79(11):2923-2932. doi: 10.1158/0008-5472.CAN-18-2540. Epub 2019 Apr 17. PMID: 30996048;

Interested individuals should submit as a single PDF that includes: 1) a cover letter outlining their interest and experience in relation to this posting and 2) resume.

This position is a 2-year term limited appointment.

Internal Number: 275042