Research Assistant/Associate in Prostate Cancer Liver Metastases

Research Assistant £33,951 to £35,608 per annum

Research Associate £36,636 per annum

The Role

This 4-year Prostate Cancer UK-funded project will investigate how obesity-induced metabolic dysfunction-associated steatotic liver disease (MASLD) creates a permissive hepatic microenvironment for prostate cancer liver metastases (PCLM) and contributes to treatment resistance. The postholder will work across the research groups of Dr Jack Leslie and Dr Emma Scott to establish and analyse pre-clinical mouse models of obesity/MASLD and PCLM, including therapeutic intervention studies, and will use immunological, histological and molecular approaches to define how the liver microenvironment is remodelled during metastatic progression and therapy. A particular focus will be on neutrophils and CD8+ T cells and on responses to androgen receptor-targeted therapy, with the overarching aim of identifying mechanisms that can be targeted to improve treatment responses in PCLM.

As part of our commitment to career development for research colleagues, the University has developed 3 levels of Research Innovation Role Profiles.pdf. These profiles set out firstly the generic competencies and responsibilities expected of role holders at each level and, secondly, the general qualifications and experiences needed for entry at a particular level.

Find out more about the Faculty of Medical Sciences here: https://www.ncl.ac.uk/medical-sciences/
Find out more about our Research Institutes: https://www.ncl.ac.uk/medical-sciences/research/institutes/

Contact for the post is Dr Jack Leslie (jack.leslie@newcastle.ac.uk)

Duration of post is until 30 September 2030, full time.