Job Description

The Sahoo Lab at the Fralin Biomedical Research Institute studies the genetic and functional mechanisms that drive bone marrow failure, clonal hematopoiesis, and progression to MDS and AML. We integrate genomic and functional approaches on patient derived samples, iPSC and mouse disease models to uncover mechanisms and therapeutic vulnerabilities.

Current project areas include:

Germline predisposition to MDS and AML: mechanisms by which inherited mutations cause hematopoietic failure and predispose to leukemogenesis
Chromosome 7 aneuploidy syndromes: modeling monosomy 7 associated bone marrow failure and its role in clonal selection
Clonal evolution and therapeutic vulnerabilities: using single cell sequencing to track clonal dynamics and to identify targets in high risk MDS and AML

Position Summary: We seek a full-time Research Associate to support cellular and in vivo studies. The role requires strong proficiency in wet-lab techniques, including molecular biology and mammalian cell culture. Experience with induced pluripotent stem cells is required. Mouse handling for hematopoietic studies is also required. Candidates without prior experience must be clearly willing to learn.

Required Qualifications

Master's degree in biology and significant professional experience and equitable laboratory experience
Expertise in experimental design and execution
Effective organizational and time management skills
Ability to work independently and as part of a collaborative team
Excellent communication skills
Extensive primary cell culture expertise

Preferred Qualifications

Experience with general mouse hematopoiesis and hematopoietic cancer models
Familiarity with CRISPR-based genome editing and functional screens

Overtime Status: Exempt: Not eligible for overtime

Appointment Type: Restricted

Salary Information: Commensurate with experience

Hours per week: 40+

Review Date: 10/10/25

Additional Information: The successful candidate will be required to have a criminal conviction check.

Virginia Tech

Blacksburg, VA, USA

"Research Associate"

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