The Crossley Lab at the world-leading CRUK Cambridge Institute is recruiting an enthusiastic and collaborative Postdoctoral Researcher to help uncover the mechanisms by which RNA-DNA hybrids contribute to human disease and how these pathways can be exploited for cancer diagnosis and treatment.
This is an exciting opportunity to join the group at a formative stage, supported by long-term funding from Cancer Research UK and the Wellcome Trust, and to shape a research programme aligned with your expertise and interests.
Research Opportunities
Projects within the lab span:
- Genome biology of pathological R-loops and their impact on genome stability in cancer and neurodegeneration.
- Cytoplasmic RNA-DNA hybrids and their role in innate immune signalling.
- Extracellular RNA-DNA hybrid release and communication between cells.
- Genomics and computational approaches to study RNA-DNA hybrids in cellular and patient-derived samples.
Why Join Us?
- Exciting science at the intersection of genome stability, immunity and cancer biology.
- Opportunities to develop and apply cutting-edge approaches including long-read sequencing, proteomics, quantitative imaging and functional genomics.
- Strong support for publications, fellowship applications and career development.
- Access to world-class facilities, high-performance computing and specialist training.
- A highly collaborative research environment on the Cambridge Biomedical Campus, alongside Addenbrooke's Hospital, the MRC Laboratory of Molecular Biology, EMBL-EBI and the Wellcome Sanger Institute.
About You
You will have:
- A PhD in a relevant discipline (awarded or submitted prior to appointment).
- A strong interest in cancer biology, genome biology, RNA biology, immunology, computational biology or a related field.
- Excellent scientific, communication and collaborative skills.
Whether your background is experimental, computational, or a combination of both, we welcome applications from researchers who are excited to contribute to a rapidly emerging area of biology with significant translational potential.
Find out more about the Crossley Lab: https://www.cruk.cam.ac.uk/research-groups/crossley-group/
Join us and help advance discoveries that could transform our understanding of cancer and other human diseases.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please quote reference SW51133 on your application and in any correspondence about this vacancy.
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