Title
Research Associate (HIV Epidemiology and Modelling)
School
Harvard T.H. Chan School of Public Health
Department/Area
Epidemiology
The Department of Epidemiology at the Harvard T.H. Chan School of Public Health studies the frequency, distribution, and determinants of disease in humans, a fundamental science of public health. In addition to pursuing ground-breaking global research initiatives, we educate and prepare future medical leaders and practitioners as part of our mission to ignite positive changes in the quality of health across the world.
We seek an outstanding Research Associate to lead development of a epidemiological, statistical, and mathematical modelling research portfolio as part of two NIH-funded studies (IN-STEP and SENTINEL) with the Rakai Community Cohort Study (RCCS) in south-central Uganda. Both projects are collaborations with the Rakai Health Sciences Program (RHSP) and Johns Hopkins University, and other study team partners.
The Research Associate will have primary responsibility for only one project aligned with skills and interests, but is expected to collaborate with and co-supervise other team members across both projects, along with collaboration with other modeling teams at the Gates Foundation and Imperial College London.
Successful candidates for the Research Associate role will have at least 2-3 years of postdoctoral research experience, demonstrate a successful track record of innovative and academically productive research, and an intention and ability to progress towards a role as an independent investigator, including designing implementation research plans to deliver on project aims, managing partnerships with project collaborators and stakeholders, co-supervising and mentoring research team members, and developing research ideas and grant proposals.
The Research Associate will be based in the Center for Communicable Disease Dynamics in the Department of Epidemiology at the Harvard T.H. Chan School of Public Health. They will be a member of the HIV Inference Group, a geographically distributed and substantively diverse research team led by Dr. Jeff Imai-Eaton. Both projects are close collaborations with the Rakai Health Sciences Program (Dr. Godfrey Kigozi, Dr. Ronald Galiwango, and colleagues) and Johns Hopkins University (Dr. M. Kate Grabowski and Dr. Larry Chang).
Please read below for additional information about the study and the two projects. As mentioned above, the Research Associate will take primary responsibility for one project and collaborate on the other.
Position Description
The Rakai Community Cohort Study. The RCCS, run by the Rakai Health Sciences Program, is one of the longest-running and largest population-based HIV surveillance cohorts in Africa. Since 1994, the RCCS has enumerated and surveyed all residents aged 15 years and older in about 40 communities in south-central Uganda roughly every two years. Each round collects detailed sociodemographic, behavioural, and health-service data, along with HIV and other laboratory testing, from about 20,000 participants. Biospecimens have been collected from more than 300,000 individuals. Over four decades, research in Rakai has shaped the global HIV response. It established the relationship between viral load and heterosexual HIV transmission, showed through randomised trials that medical male circumcision reduces HIV acquisition in men, documented the impact of combination HIV prevention and treatment on population-wide HIV incidence declines, and has pioneered the use of population-based HIV phylogenetics to unravel HIV transmission networks. The RCCS is now uniquely positioned to map the “end game” of a generalised HIV epidemic. As incidence falls, it can show where remaining infections occur, which interventions work, and what threatens progress toward epidemic control.
Project 1: IN-STEP. IN-STEP (Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control through PrEP) is an individually randomised effectiveness-implementation trial nested within the RCCS to assess whether integrated STI testing increases uptake and continuation of HIV pre-exposure prophylaxis (PrEP) and improves STI outcomes, hypothesized through multiple pathways including leveraging ongoing STI transmission for efficient network-targeted interventions and STI diagnosis supporting enhanced individual motivation for HIV prevention. As part of IN-STEP, the HSPH team will lead development of a transmission modelling framework that simulates simultaneous transmission of HIV and multiple curable STIs within the same sexual networks and test apply the model to test network-science approaches to HIV and STI control. The model will be developed in collaboration with professional research simulation platform developers at the Gates Foundation Institute for Disease Modeling, and calibrated to empirical data from the RCCS and IN-STEP.
Project 2: SENTINEL. SENTINEL leverages longitudinal epidemiologic data and HIV genomic sequencing collected in the RCCS to address critical questions about how HIV infection dynamics in eastern and southern Africa evolve as incidence falls and assess emerging threats to HIV epidemic control. The HSPH team will lead longitudinal statistical analysis and mathematical modelling to understand current transmission dynamics, sources of infection, whether new infections and transmission are increasingly concentrated in key populations or other identifiable subgroups, and project the impact of alternative HIV prevention and treatment strategies in the low-incidence era. Results will be applied to guide regional program strategies and surveillance priorities.
Education Requirements
- PhD in Infectious Disease Epidemiology, Epidemiology, Biostatistics, Statistics, Population Biology, Demography, or a related quantitative discipline
Experience & Skills Requirements
Basic Qualifications
- 2-3 years postdoctoral research experience with demonstrated track record of innovative research and academic productivity
- Experience independently developing, leading, and delivering research projects
- Research experience in analysis of population-based cohort, trial, surveillance, or population health data
- Research experience in infectious disease epidemiology and transmission dynamics
- Experience with mathematical modelling of infectious diseases
- Experience with applied statistical modelling, such as regression, longitudinal, hierarchical, or Bayesian models
- Strong quantitative background, with demonstrated ability to program in one or more scientific programming languages, e.g. R, Python, C++
Preferred Experience
- Knowledge of HIV and/or STI epidemiology and prevention in eastern and southern Africa
- Experience analysing longitudinal cohort data or randomised trial data
- Experience working multidisciplinary collaborative teams in hybrid research environments
- For SENTINEL: familiarity with HIV phylogenetics or pathogen genomic data, or with incidence estimation methods
- For IN-STEP: experience with agent-based or network modelling of infectious disease transmission
Preferred Skills
Additional Qualifications
- Experience with modern Bayesian computing and probabilistic modelling tools such as Stan, TMB, INLA, or PyMC
- Experience with causal inference methods, multi-level models, or transmission-dynamic models
- Experience with reproducible research and team science workflows (e.g. Git/GitHub)
- Proven research skills and a record of first-author publications
- Excellent verbal and written communication skills, including the ability to communicate technical results to non-specialist and policy audiences
- Ability to work independently and as part of a larger, interdisciplinary, and geographically distributed team
- Comfort operating with ambiguity and working collaboratively in diverse cultural contexts
- Willingness and ability to travel internationally, including to Uganda
Additional Information: Per university guidelines, postdoc appointments are considered to be on-campus, full-time positions. Per university payroll tax guidelines all applicants must reside in an acceptable payroll states or be willing to relocate to: Massachusetts, New Hampshire, Rhode Island, Maine, Connecticut, Maryland, Vermont, New York, California, New Jersey, Virginia, Washington, Georgia, or Illinois.
Special Instructions
Cover Letter: Candidates should (1) specifically document qualifications and readiness for Research Associate level appointment, and (2) describe how interests and experience relates to either or both projects IN-STEP and SENTINEL.
Optional Supporting Materials: Candidates may provide links to up to two relevant publications or preprints.
Contact Information
For additional questions about the position, please contact Jeffrey Imai-Eaton, PhD, Associate Professor of Epidemiologyin the Department of Epidemiology.
Contact Email
jeaton@hsph.harvard.edu
Salary Range
$85,000 – $92,000
Compensation will be based on post-graduate (PGY) experience
Minimum Number of References Required 2
Maximum Number of References Allowed 2
Keywords
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Supplemental Questions
Required fields are indicated with an asterisk (*).
Applicant Documents
Required Documents
- Curriculum Vitae
- Cover Letter
Optional Documents
- Publication
- Publication 2