Research Associate - Medicinal Chemistry

Job Duties

• Conducts research experiments involving the synthesis of small molecule ligands that can be conjugated with pyrrole-imidazole polyamides for therapeutic applications.
• Performs multi-step syntheses of pyrrole-imidazole polyamides via manual solid-phase synthesis using Fmoc- and Boc-protected amino acids.
• Conjugates polyamides to small molecules using standard coupling chemistry with various linker designs.
• Purifies compounds by reverse-phase HPLC and conducts basic characterization using NMR and MALDI-TOF mass spectrometry.
• Maintains detailed laboratory notebooks and present findings at lab meetings.
• Conducts literature searches to support ongoing projects and complies information in formats requested by the PI.
• Assists in optimizing linker chemistries and conjugation strategies under PI guidance.
• Prepares fluorescently labeled analogs following established protocols for uptake studies.
• Participates in troubleshooting and improving synthetic routes, escalating complex challenges to senior lab members.
• Maintains an accurate chemical inventory, supports purchasing needs, and helps ensure compliance with laboratory safety expectations.
• Performs other job related duties as assigned.

Minimum Qualifications

• Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
• Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Preferred Qualifications

• Experience with organic synthesis, peptide or oligomer assembly, or heterocyclic chemistry.
• Familiarity with HPLC purification, NMR sample preparation, and mass spectrometry.
• Strong organizational skills, attention to detail, and the ability to follow complex protocols.
• Demonstrated ability to work collaboratively in a research laboratory.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.