Research Fellow

About the role

An opportunity has become available to join a research group at the UCL Great Ormond Street Institute of Child Health in a research project to develop drug switchable chimeric antigen receptors targeting childhood solid cancers. The appointee will join the group to complete the last approximately 15 months of a 3 year project and so previous experience in CAR-T cell molecular cloning and functional assays including in vivo assays is essential. The appointee will be integrated into the preclinical team run by Professor John Anderson in the Zayed Centre at the Institute of Child Health focused on development of CAR-T therapeutics for paediatric cancers. There will be close working with collaboration partners. Flexibility in working hours will be required to accommodate weekend or out of hours tasks if required. The Zayed Centre for research in rare disease in childhood is a new research facility in the UCL Institute of Child Health. Five Principal Investigators share research space. The appointment is for 9 months. The appointee will fall under the overall line management of Professor John Anderson. Main purpose summarised as follows:

• Generating variants of chimeric receptors for transduction into human T cells using molecular cloning techniques.
• Performing Functional immune assays of CAR-T candidates evaluated by multiparametric flow cytometry
• Evaluation of new CAR-T products in multi-arm animal therapeutics trials in tumour bearing mice.
• Working under line management of Prof Anderson and with day-to-day monitoring and supervision by members of the research laboratory team.
• Working within a team of scientists with focus on development of new therapies for childhood cancer
• Writing up of results for scientific publication

Duties and responsibilities:

• Ensuring data integrity and excellent record keeping
• Performing experimental assays for designated projects as directed by the PI
• Org anising and leading and executing multi-arm in vivo studies using experimental mice
• Ensuring compliance with GCLP and the HTA

The salary offered in this post is £45,103 per annum and is funded for approximately 9 months in the first instance.

About you

Team working, aptitude and excellent record-keeping and communication skills will be essential. Responsibilities will include the analysis of samples from experimental therapeutics studies using techniques such as flow cytometry (previous experience essential), routine maintenance of cells in culture (primary cells and cell lines), and hands on work in mouse based in vivo studies of cancer models (previous experience and current home office license essential). Customer advert reference: B02-09409