"Research Investigator Sr."

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Job Description Summary
Design and execute experiments to elucidate the molecular structures of novel chemical entities (NCEs) and their radiolabeled counterparts.
· Develop and optimize radiochemical methods for the radiolabeling of NCEs with various radioisotopes, including but not limited to F-18, Ga-68, Tc-99m, I-125, Lu-177, and Ac-225.
· Optimize radiochemical yields through systematic experimentation and method refinement.
· Establish and validate analytical quality control methods using techniques such as HPLC, TLC, and LC-MS for the characterization and assay of radiolabeled compounds and their precursors.
· Conduct hands-on radiolabeling experiments in compliance with safety and regulatory standards.
· Collaborate with interdisciplinary teams including synthetic chemists, pharmacologists, and imaging scientists to support research and development efforts.
· Maintain detailed records of experimental procedures, data analysis, and results in laboratory notebooks and databases.

Job Responsibilities
· Design and execute experiments to elucidate the molecular structures of novel chemical entities (NCEs) and their radiolabeled counterparts.
· Develop and optimize radiochemical methods for the radiolabeling of NCEs with various radioisotopes, including but not limited to F-18, Ga-68, Tc-99m, I-125, Lu-177, and Ac-225.
· Optimize radiochemical yields through systematic experimentation and method refinement.
· Establish and validate analytical quality control methods using techniques such as HPLC, TLC, and LC-MS for the characterization and assay of radiolabeled compounds and their precursors.
· Conduct hands-on radiolabeling experiments in compliance with safety and regulatory standards.
· Collaborate with interdisciplinary teams including synthetic chemists, pharmacologists, and imaging scientists to support research and development efforts.
· Maintain detailed records of experimental procedures, data analysis, and results in laboratory notebooks and databases.
· Other duties as assigned
Position is contingent upon grant funding

Qualifications
Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.

Job Location
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$79,500.00 - $94,753.00 Annual Rate