Research Investigator Sr.

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

Job Description Summary

Design and execute experiments to elucidate the molecular structures of novel chemical entities (NCEs) and their radiolabeled counterparts.

• Develop and optimize radiochemical methods for the radiolabeling of NCEs with various radioisotopes, including but not limited to F-18, Ga-68, Tc-99m, I-125, Lu-177, and Ac-225.
• Optimize radiochemical yields through systematic experimentation and method refinement.
• Establish and validate analytical quality control methods using techniques such as HPLC, TLC, and LC-MS for the characterization and assay of radiolabeled compounds and their precursors.
• Conduct hands-on radiolabeling experiments in compliance with safety and regulatory standards.
• Collaborate with interdisciplinary teams including synthetic chemists, pharmacologists, and imaging scientists to support research and development efforts.
• Maintain detailed records of experimental procedures, data analysis, and results in laboratory notebooks and databases.

Job Responsibilities

• Design and execute experiments to elucidate the molecular structures of novel chemical entities (NCEs) and their radiolabeled counterparts.
• Develop and optimize radiochemical methods for the radiolabeling of NCEs with various radioisotopes, including but not limited to F-18, Ga-68, Tc-99m, I-125, Lu-177, and Ac-225.
• Optimize radiochemical yields through systematic experimentation and method refinement.
• Establish and validate analytical quality control methods using techniques such as HPLC, TLC, and LC-MS for the characterization and assay of radiolabeled compounds and their precursors.
• Conduct hands-on radiolabeling experiments in compliance with safety and regulatory standards.
• Collaborate with interdisciplinary teams including synthetic chemists, pharmacologists, and imaging scientists to support research and development efforts.
• Maintain detailed records of experimental procedures, data analysis, and results in laboratory notebooks and databases.
• Other duties as assigned. Position is contingent upon grant funding.

Qualifications

Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.

Job Location

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$79,500.00 - $94,753.00 Annual Rate