Research Laboratory Tech Sr

experiments, as well as maintain and work with mouse colonies used for research. Core responsibilities include molecular cloning, DNA preparation, PCR, protein expression and analysis, mouse breeding and genotyping, maintenance of animal records, preparation of experimental cohorts, therapeutic administration, tissue and sample collection, and experimental data organization and analysis. The technician will work closely with graduate students, postdoctoral fellows, and other laboratory personnel under the supervision of the Principal Investigator. Maintain mouse colonies, including breeding, weaning, identification, genotyping, record-keeping, and preparing experimental cohorts. Participate in animal therapeutic studies, including mouse handling, administering experimental therapeutics, health monitoring, and sample/tissue collection. Perform molecular biology techniques, including PCR, DNA and plasmid preparation, molecular cloning, and sequence verification. Perform protein biochemistry experiments, including recombinant protein expression and purification, sample preparation, SDS-PAGE, immunoblotting, and related assays. Assist with laboratory operations, including preparing reagents and buffers, maintaining laboratory inventories, and organizing experimental data and records. Work collaboratively with laboratory members to execute experiments and troubleshoot procedures. Maintain accurate, detailed records for all experiments and animal care while adhering strictly to university safety and animal-use requirements. Bachelor's degree in biology, biochemistry, biomedical sciences, molecular biology, neuroscience, pharmaceutical sciences, biomedical engineering, or a closely related biological/biomedical science field. Previous laboratory research experience acquired through undergraduate research, internships, employment, or equivalent laboratory training. Basic knowledge of molecular biology and biochemistry principles. Excellent organizational skills, strong attention to detail, and a proven ability to maintain accurate, thorough experimental records. Willingness to work with laboratory mice and complete all required university animal-use and laboratory safety training. Prior experience working with laboratory mice including handling, breeding, weaning, genotyping, injections, therapeutic studies, or tissue collection is highly desirable. Hands-on experience with techniques such as PCR, molecular cloning, recombinant protein expression and purification, immunoblotting, ELISA, or related biochemical assays. Experience working in an academic biomedical research laboratory and familiarity with maintaining organized experimental records. This is a 3-year term-limited position, with the possibility of extension based on funding availability. The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act. The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.